（-）-帕罗西汀的不对称形式合成。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-30 Epub Date: 2025-05-19 DOI:10.1021/acs.orglett.5c01622

Lei Liu, Xianjing Zhou, Wenfeng Huang, Sunliang Cui

引用次数: 0

摘要

报道了一种简洁、不对称的(-)-帕罗西汀形式化合成方法。该合成策略以不对称氢化反应构建手性中心和磷酸基参与的分子内SN2反应构建反式3,4-二取代哌啶支架为特点。该合成路线简洁实用，可用于(-)-帕罗西汀的合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Asymmetric Formal Synthesis of (-)-Paroxetine.

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Asymmetric Formal Synthesis of (-)-Paroxetine.

A concise, asymmetric formal synthesis of (-)-paroxetine is reported. The synthetic strategy features an asymmetric hydrogenation for constructing the chiral center and a phosphate-group-involved intramolecular S_N2 reaction for the construction of the trans-3,4-disubstituted piperidine scaffold. This synthetic route is concise and practical for (-)-paroxetine synthesis.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.