α-突触核蛋白分子探针在帕金森病早期诊断中的应用潜力:以影像学方法为重点

IF 3.9 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Qiyuan Sun, Mingmin Wu, Runxia Xie, Lingfeng Lai, Qiujie Chen and Jitian Guan*, 
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引用次数: 0

摘要

本文旨在探讨α-突触核蛋白(α-syn)分子探针在帕金森病(PD)早期诊断中的潜在应用,特别是通过医学影像学方法进行系统评价。近年来,α-syn在中枢神经系统内的异常聚集被认为是PD病理生理的主要驱动因素,巩固了其作为诊断和预后的重要生物标志物的作用。PD的早期诊断对于实现精确的治疗干预和减轻神经退行性进展至关重要,从而提高长期功能结果和生活质量。然而,临床实践中仍然存在挑战,特别是在诊断时间晚和缺乏特异性生物标志物方面。通过分析现有文献,我们将评估不同成像技术联合α-syn探针的有效性,并讨论其在临床应用中的优势和局限性。这些成像方法可以提供早期病理变化的可视化,有助于提高PD的识别率。最后,我们强调了未来研究探索新的分子探针和成像技术的重要性,这些技术可以提高PD的早期诊断率和治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploring the Application Potential of α-Synuclein Molecular Probes in Early Diagnosis of Parkinson’s Disease: Focus on Imaging Methods

This review aims to explore the potential application of α-synuclein (α-syn) molecular probes in the early diagnosis of Parkinson’s disease (PD), particularly through systematic evaluation using medical imaging methods. In recent years, The abnormal aggregation of α-syn within the central nervous system is now recognized as a central driver of PD pathophysiology, solidifying its role as a critical diagnostic and prognostic biomarker. Early diagnosis of PD is critical for enabling precision therapeutic interventions and mitigating neurodegenerative progression, thereby enhancing long-term functional outcomes and the quality of life. However, challenges remain in clinical practice, particularly concerning the late timing of diagnosis and the lack of specific biomarkers. By analyzing the existing literature, we will assess the effectiveness of different imaging techniques combined with α-syn probes and discuss their advantages and limitations in clinical applications. These imaging methods can provide visualization of early pathological changes, helping to improve the recognition rate of PD. Finally, we emphasize the importance of future research to explore new molecular probes and imaging technologies that can improve early diagnosis rates and treatment outcomes for PD.

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来源期刊
ACS Chemical Neuroscience
ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL
CiteScore
9.20
自引率
4.00%
发文量
323
审稿时长
1 months
期刊介绍: ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research
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