{"title":"α-突触核蛋白分子探针在帕金森病早期诊断中的应用潜力:以影像学方法为重点","authors":"Qiyuan Sun, Mingmin Wu, Runxia Xie, Lingfeng Lai, Qiujie Chen and Jitian Guan*, ","doi":"10.1021/acschemneuro.5c0000810.1021/acschemneuro.5c00008","DOIUrl":null,"url":null,"abstract":"<p >This review aims to explore the potential application of α-synuclein (α-syn) molecular probes in the early diagnosis of Parkinson’s disease (PD), particularly through systematic evaluation using medical imaging methods. In recent years, The abnormal aggregation of α-syn within the central nervous system is now recognized as a central driver of PD pathophysiology, solidifying its role as a critical diagnostic and prognostic biomarker. Early diagnosis of PD is critical for enabling precision therapeutic interventions and mitigating neurodegenerative progression, thereby enhancing long-term functional outcomes and the quality of life. However, challenges remain in clinical practice, particularly concerning the late timing of diagnosis and the lack of specific biomarkers. By analyzing the existing literature, we will assess the effectiveness of different imaging techniques combined with α-syn probes and discuss their advantages and limitations in clinical applications. These imaging methods can provide visualization of early pathological changes, helping to improve the recognition rate of PD. Finally, we emphasize the importance of future research to explore new molecular probes and imaging technologies that can improve early diagnosis rates and treatment outcomes for PD.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 10","pages":"1838–1846 1838–1846"},"PeriodicalIF":3.9000,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acschemneuro.5c00008","citationCount":"0","resultStr":"{\"title\":\"Exploring the Application Potential of α-Synuclein Molecular Probes in Early Diagnosis of Parkinson’s Disease: Focus on Imaging Methods\",\"authors\":\"Qiyuan Sun, Mingmin Wu, Runxia Xie, Lingfeng Lai, Qiujie Chen and Jitian Guan*, \",\"doi\":\"10.1021/acschemneuro.5c0000810.1021/acschemneuro.5c00008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >This review aims to explore the potential application of α-synuclein (α-syn) molecular probes in the early diagnosis of Parkinson’s disease (PD), particularly through systematic evaluation using medical imaging methods. In recent years, The abnormal aggregation of α-syn within the central nervous system is now recognized as a central driver of PD pathophysiology, solidifying its role as a critical diagnostic and prognostic biomarker. Early diagnosis of PD is critical for enabling precision therapeutic interventions and mitigating neurodegenerative progression, thereby enhancing long-term functional outcomes and the quality of life. However, challenges remain in clinical practice, particularly concerning the late timing of diagnosis and the lack of specific biomarkers. By analyzing the existing literature, we will assess the effectiveness of different imaging techniques combined with α-syn probes and discuss their advantages and limitations in clinical applications. These imaging methods can provide visualization of early pathological changes, helping to improve the recognition rate of PD. Finally, we emphasize the importance of future research to explore new molecular probes and imaging technologies that can improve early diagnosis rates and treatment outcomes for PD.</p>\",\"PeriodicalId\":13,\"journal\":{\"name\":\"ACS Chemical Neuroscience\",\"volume\":\"16 10\",\"pages\":\"1838–1846 1838–1846\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-05-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.acs.org/doi/epdf/10.1021/acschemneuro.5c00008\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Chemical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acschemneuro.5c00008\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Chemical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acschemneuro.5c00008","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Exploring the Application Potential of α-Synuclein Molecular Probes in Early Diagnosis of Parkinson’s Disease: Focus on Imaging Methods
This review aims to explore the potential application of α-synuclein (α-syn) molecular probes in the early diagnosis of Parkinson’s disease (PD), particularly through systematic evaluation using medical imaging methods. In recent years, The abnormal aggregation of α-syn within the central nervous system is now recognized as a central driver of PD pathophysiology, solidifying its role as a critical diagnostic and prognostic biomarker. Early diagnosis of PD is critical for enabling precision therapeutic interventions and mitigating neurodegenerative progression, thereby enhancing long-term functional outcomes and the quality of life. However, challenges remain in clinical practice, particularly concerning the late timing of diagnosis and the lack of specific biomarkers. By analyzing the existing literature, we will assess the effectiveness of different imaging techniques combined with α-syn probes and discuss their advantages and limitations in clinical applications. These imaging methods can provide visualization of early pathological changes, helping to improve the recognition rate of PD. Finally, we emphasize the importance of future research to explore new molecular probes and imaging technologies that can improve early diagnosis rates and treatment outcomes for PD.
期刊介绍:
ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following:
Neurotransmitters and receptors
Neuropharmaceuticals and therapeutics
Neural development—Plasticity, and degeneration
Chemical, physical, and computational methods in neuroscience
Neuronal diseases—basis, detection, and treatment
Mechanism of aging, learning, memory and behavior
Pain and sensory processing
Neurotoxins
Neuroscience-inspired bioengineering
Development of methods in chemical neurobiology
Neuroimaging agents and technologies
Animal models for central nervous system diseases
Behavioral research