n -烯丙基酮胺和炔基碱介导合成多取代吡咯：碳离子的相互作用。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-20 DOI:10.1021/acs.orglett.5c01545

Ivan A Bidusenko,Elena Yu Schmidt,Anastasia A Kvashnina,Igor A Ushakov,Boris A Trofimov

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引用次数: 0

摘要

末端（het）芳基乙炔与N-烯丙基酮胺反应（KOBut/DMSO, 60°C， 1小时）产生2-(het)芳基-4-(het)芳基甲基-5-乙基吡咯，由于乙炔和偶氮碳离子与C=N和C≡C键相互作用，产率高达71%。这个新的反应为合成和具有药用前景的化合物打开了一锅通道。

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Base-Mediated Synthesis of Polysubstituted Pyrroles from N-Allyl Ketimines and Alkynes: Interplay of Carbanions.

Terminal (het)arylacetylenes react (KOBut/DMSO, 60 °C, 1 h) with N-allyl ketimines to afford 2-(het)aryl-4-(het)arylmetyl-5-ethylpyrroles in up to 71% yield as a result of the interaction of acetylenic and azadienic carbanions with C=N and C≡C bonds. This new reaction opens a one-pot access to synthetically and pharmaceutically prospective compounds.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.