YY1在生殖系统中的作用综述。

IF 4.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemico-Biological Interactions Pub Date : 2025-05-15 DOI:10.1016/j.cbi.2025.111560

Yinan Wang , Songming He , Qin Huang , Jing Yang , Chaogang Yang , Jinli Ding

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引用次数: 0

摘要

阴阳1 （Yin Yang 1, YY1）是一种高度保守的多功能转录因子，具有细胞增殖、分化和转录调控等多种生物学功能。近年来，YY1在包括人类在内的动物生殖组织中的功能活性的发现引起了越来越多的关注。YY1在卵泡、胚胎和胎盘的发育以及精子发生中起重要作用。此外，YY1在不育、多囊卵巢综合征、复发性自然流产（RSA）、妇科肿瘤等生殖疾病中的作用已得到证实。本文旨在系统介绍YY1在生殖系统中的表达和功能，为今后的研究方向提供新的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The roles of YY1 in reproductive system: an overview

Yin Yang 1 (YY1) is a highly conserved multifunctional transcription factor with multiple biological functions including cell proliferation, differentiation and transcriptional regulation. In recent years, the discovery of the functional activity of YY1 in the reproductive tissues of animals, including humans has attracted more and more attention. YY1 plays important roles in the development of follicular, embryo and placenta, as well as spermatogenesis. In addition, the role of YY1 in reproductive diseases including infertility, polycystic ovarian syndrome, recurrent spontaneous abortion (RSA), and gynecological tumor has been demonstrated. In the present review, we aimed to systematically introduce the expression and functions of YY1 in the reproductive system, providing new recommendations for future research areas.

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来源期刊

Chemico-Biological Interactions 生物-毒理学

CiteScore

7.70

自引率

3.90%

发文量

410

审稿时长

36 days

期刊介绍： Chemico-Biological Interactions publishes research reports and review articles that examine the molecular, cellular, and/or biochemical basis of toxicologically relevant outcomes. Special emphasis is placed on toxicological mechanisms associated with interactions between chemicals and biological systems. Outcomes may include all traditional endpoints caused by synthetic or naturally occurring chemicals, both in vivo and in vitro. Endpoints of interest include, but are not limited to carcinogenesis, mutagenesis, respiratory toxicology, neurotoxicology, reproductive and developmental toxicology, and immunotoxicology.