从诱导多能干细胞(iPSC)到通用免疫细胞:新一代肿瘤治疗进展的文献综述

IF 1.5 4区 医学 Q4 ONCOLOGY
Translational cancer research Pub Date : 2025-04-30 Epub Date: 2025-04-15 DOI:10.21037/tcr-24-1087
Jing Zhang, Zixuan Jia, Huixin Pan, Wen Ma, Youhan Liu, Xuewen Tian, Yang Han, Qinglu Wang, Caixia Zhou, Jing Zhang
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引用次数: 0

摘要

背景与目的:肿瘤治疗仍然是临床的一大挑战,肿瘤免疫治疗越来越受到人们的关注。T细胞和自然杀伤细胞(NK)在免疫应答中起着至关重要的作用。诱导多能干细胞(iPSC)技术为生产功能改良的通用iPSC衍生嵌合抗原受体(CAR- T)和iPSC衍生CAR- nk (CAR- ink)细胞开辟了一条新途径。本研究旨在全面综述ipsc衍生的通用CAR-iT和CAR-iNK细胞的产生和临床应用,探讨其在癌症免疫治疗中的潜力和未来发展方向。方法:检索EBSCO、PubMed和Web of Science数据库1975 - 2024年iPSCs转化为通用免疫细胞的相关文献。关键内容和发现:iPSC技术能够生成增强型CAR-iNK细胞。基因修饰可以增强ipsc衍生免疫细胞的抗肿瘤活性。CAR-iT细胞有细胞毒性问题。相比之下,CAR-iNK细胞具有优势,因为它们可以来自不同的来源,并通过基因工程进行增强。结论:本文综述了iPSC技术在肿瘤学中的应用、iNK细胞的特性以及CAR细胞在肿瘤治疗中的优缺点。它还关注CAR-iT和CAR-iNK疗法的临床现状和修改策略,促进未来有效的现成血细胞疗法的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapies.

Background and objective: Tumor therapy is still a tough clinical challenge, and cancer immunotherapy has drawn increasing attention. T cells and natural killer (NK) cells play crucial roles in the immune response. Induced pluripotent stem cell (iPSC) technology opens up a new way to produce functionally improved universal iPSC-derived chimeric antigen receptor (CAR) T (CAR-iT) and iPSC-derived CAR-NK (CAR-iNK) cells. This study aims to comprehensively review the generation and clinical applications of iPSC-derived universal CAR-iT and CAR-iNK cells to explore their potential and future directions in cancer immunotherapy.

Methods: We searched EBSCO, PubMed, and Web of Science databases for relevant literature from 1975 to 2024 on the transformation of iPSCs into universal immune cells.

Key content and findings: iPSC technology enables the generation of enhanced CAR-iNK cells. Genetic modifications can boost the antitumor activity of iPSC-derived immune cells. CAR-iT cells have cytotoxicity issues. In contrast, CAR-iNK cells have advantages as they can be sourced from different origins and enhanced via genetic engineering.

Conclusions: This review outlines iPSC technology's application in oncology, iNK cells' properties, and the pros and cons of CAR cells in cancer treatment. It also focuses on the current clinical status and modification strategies of CAR-iT and CAR-iNK therapies, facilitating the development of future effective off-the-shelf blood cell therapies.

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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
252
期刊介绍: Translational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; http://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in Science Citation Index Expanded (SCIE). TCR publishes laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer; results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients. The focus of TCR is original, peer-reviewed, science-based research that successfully advances clinical medicine toward the goal of improving patients'' quality of life. The editors and an international advisory group of scientists and clinician-scientists as well as other experts will hold TCR articles to the high-quality standards. We accept Original Articles as well as Review Articles, Editorials and Brief Articles.
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