糖尿病视网膜病变患者血清前脑利钠肽与光学相干断层扫描指标的相关性

IF 1.8 3区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Vision Pub Date : 2025-03-28 eCollection Date: 2025-01-01

Shivani Chaturvedi, Sandeep Saxena, Apjit Kaur, Pramod Kumar, Shivani Pandey, Abbas Ali Mahdi, Levent Akduman

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引用次数: 0

摘要

目的：血清脑利钠肽（BNP）是一种由108个氨基酸组成的激素原，可抑制血管内皮生长因子（VEGF）的分泌，保护周细胞免于细胞死亡，减少视网膜血管化。本研究旨在探讨糖尿病视网膜病变患者血清bnp前体与光学相干断层扫描（OCT）指标的相关性。方法：本横断面研究调查了96名年龄在40至65岁之间的连续受试者：对照组n = 24，无糖尿病视网膜病变（NoDR） n = 24，非增生性糖尿病视网膜病变（NPDR） n = 24，增生性糖尿病视网膜病变（PDR） n = 24。当日分析血样血清pro-BNP水平，采用光谱域OCT （SD-OCT）测量以下OCT指标：OCT血管造影（OCTA）浅血管密度（SVD）、深血管密度（DVD）、中央凹无血管区（FAZ）；OCT视网膜神经纤维层（RNFL）；OCT神经节细胞分析（GCA）。结果：对照组、NoDR组、NPDR组、PDR组血清pro-BNP平均水平分别为14.07±11.51、27.35±11.81、280.44±106.13、122.33±43.66 pg/ml。与血清pro-BNP相关的OCT各项参数均值分别为OCTA SVD （r = - 0.360）、OCTA DVD （r = 0.408）、OCTA FAZ （r = 0.475）、OCT RNFL （r = - 0.215）、OCT GCA (r = - 0.285；结论：NPDR组血清pro-BNP水平高于NoDR组，PDR组明显低于NPDR组，反映了保护屏障的降低。这些结果与各OCT指标的变化有一定的相关性。

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Serum pro-brain natriuretic peptide correlates with optical coherence tomography indices in diabetic retinopathy.

Purpose: Serum pro-brain natriuretic peptide (BNP) is a 108-amino-acid prohormone that inhibits vascular endothelial growth factor (VEGF) secretion, protecting pericytes from cell death and decreasing retinal vascularization. The purpose of this study was to investigate the correlation of serum pro-BNP with optical coherence tomography (OCT) indices in diabetic retinopathy.

Methods: This cross-sectional study investigated 96 consecutive subjects aged between 40 and 65 years: controls n = 24, no diabetic retinopathy (NoDR) n = 24, non-proliferative diabetic retinopathy (NPDR) n = 24, and proliferative diabetic retinopathy (PDR) n = 24. Same-day analysis of blood samples for serum pro-BNP levels was performed and spectral-domain OCT (SD-OCT) was used to measure the following OCT indices: OCT angiography (OCTA) superficial vessel density (SVD), deep vessel density (DVD), and foveal avascular zone (FAZ); OCT retinal nerve fiber layer (RNFL); and OCT ganglion cell analysis (GCA).

Results: The mean serum pro-BNP levels for the control, NoDR, NPDR, and PDR groups were 14.07 ± 11.51, 27.35 ± 11.81, 280.44 ± 106.13, and 122.33 ± 43.66 pg/ml, respectively. The mean values of the various OCT parameters correlated with serum pro-BNP were OCTA SVD (r = $-$ 0.360), OCTA DVD (r = 0.408), OCTA FAZ (r = 0.475), OCT RNFL (r = $-$ 0.215) and OCT GCA (r = $-$ 0.285; p<0.001).

Conclusions: The serum pro-BNP levels were higher in the NPDR group than in the NoDR group and much lower in the PDR group than in the NPDR group, reflecting a lowering of the protective barrier. These results correlated with the changes in various OCT indices.

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来源期刊

Molecular Vision 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Molecular Vision is a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology, and the genetics of the visual system (ocular and cortical). Molecular Vision publishes articles presenting original research that has not previously been published and comprehensive articles reviewing the current status of a particular field or topic. Submissions to Molecular Vision are subjected to rigorous peer review. Molecular Vision does NOT publish preprints. For authors, Molecular Vision provides a rapid means of communicating important results. Access to Molecular Vision is free and unrestricted, allowing the widest possible audience for your article. Digital publishing allows you to use color images freely (and without fees). Additionally, you may publish animations, sounds, or other supplementary information that clarifies or supports your article. Each of the authors of an article may also list an electronic mail address (which will be updated upon request) to give interested readers easy access to authors.