fox01与糖皮质激素信号传导在促生长因子终末分化中的相互作用。

IF 3.8 3区 医学 Q2 CELL BIOLOGY
Pratyusa Das, Caitlin E. Stallings , Ridwanullah A. Abubakar, Nooshin Mojahed, Shalini Guha, Dania Abou-Jabal, Buffy S. Ellsworth
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引用次数: 0

摘要

糖皮质激素在垂体生长激素终末分化中起关键作用。然而,其机制仍然知之甚少。在这里,我们证明叉头转录因子FOXO1的缺失严重损害糖皮质激素诱导的生长激素(Gh1)基因的表达,无论是在体外还是在体内。其机制似乎涉及糖皮质激素诱导Foxo1表达,核定位以及与Gh1基因相关的结合增加。另一种机制包括糖皮质激素受体NR3C1的稳定,可能是通过fox01诱导伴侣蛋白HSP90。综上所述,这些数据表明糖皮质激素信号和FOXO1共同促进Gh1表达,这是促生长终分化的一个重要方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The interplay between FOXO1 and glucocorticoid signaling in promoting the terminal differentiation of somatotropes
Glucocorticoids play a pivotal role in terminal differentiation of pituitary somatotropes. However, the mechanisms for this remain poorly understood. Here we demonstrate that loss of the forkhead transcription factor, FOXO1, severely impairs glucocorticoid-induced expression of the gene encoding growth hormone (Gh1) both in vitro and in vivo. The mechanism appears to involve glucocorticoid induction of Foxo1 expression, nuclear localization, and increased binding associated with the Gh1 gene. An additional mechanism includes stabilization of the glucocorticoid receptor, NR3C1, possibly through FOXO1 induction of the chaperone protein, HSP90. Together these data suggest that glucocorticoid signaling and FOXO1 cooperate to promote Gh1 expression, an essential aspect of somatotrope terminal differentiation.
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来源期刊
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology 医学-内分泌学与代谢
CiteScore
9.00
自引率
2.40%
发文量
174
审稿时长
42 days
期刊介绍: Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.
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