Ki Jin Jung, Sun-Pyo Hong, Ik Dong Yoo, Sang Mi Lee, Jeong Won Lee
{"title":"儿童骨显像定量生长板摄取参数与生长速度的关系。","authors":"Ki Jin Jung, Sun-Pyo Hong, Ik Dong Yoo, Sang Mi Lee, Jeong Won Lee","doi":"10.1097/MNM.0000000000001992","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to examine the association between quantitative growth plate uptake parameters in bone scintigraphy and growth velocity among children.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 30 pediatric patients (21 male and nine female; age range, 3-15 years) who underwent planar bone scintigraphy. Ratios of maximum growth plate uptake to mean diaphyseal uptake (GPmax/D) and mean growth plate uptake to mean diaphyseal uptake (GPmean/D) were calculated for both femurs on anterior and posterior bone scintigraphy images. A total of eight GPmax/D parameters and eight GPmean/D parameters were measured. The relationships of growth plate uptake parameters with age and growth velocity (cm/year) were assessed.</p><p><strong>Results: </strong>Correlation analysis with growth velocity revealed that the anterior GPmax/D (numerical mean of GPmax/D between the right and left femurs on an anterior image) exhibited the highest correlation coefficient (0.409) among the bone scintigraphy parameters (P = 0.034). The anterior GPmax/D also demonstrated a significant negative correlation with age (P = 0.042, correlation coefficient: -0.373). In a multiple regression analysis to predict growth velocity with adjusting for age and sex, the model that included left GPmean/D (geometric mean of GPmean/D between anterior and posterior images of the left femur) yielded the highest adjusted R2 value (0.786), followed by anterior GPmax/D (0.734).</p><p><strong>Conclusion: </strong>Quantitative growth plate uptake parameters on the distal femur in bone scintigraphy are significantly associated with growth velocity. These findings suggest that growth plate uptake in bone scintigraphy could potentially serve as a predictive marker of growth in children.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of quantitative growth plate uptake parameters on bone scintigraphy with growth velocity in children.\",\"authors\":\"Ki Jin Jung, Sun-Pyo Hong, Ik Dong Yoo, Sang Mi Lee, Jeong Won Lee\",\"doi\":\"10.1097/MNM.0000000000001992\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The purpose of this study was to examine the association between quantitative growth plate uptake parameters in bone scintigraphy and growth velocity among children.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 30 pediatric patients (21 male and nine female; age range, 3-15 years) who underwent planar bone scintigraphy. Ratios of maximum growth plate uptake to mean diaphyseal uptake (GPmax/D) and mean growth plate uptake to mean diaphyseal uptake (GPmean/D) were calculated for both femurs on anterior and posterior bone scintigraphy images. A total of eight GPmax/D parameters and eight GPmean/D parameters were measured. The relationships of growth plate uptake parameters with age and growth velocity (cm/year) were assessed.</p><p><strong>Results: </strong>Correlation analysis with growth velocity revealed that the anterior GPmax/D (numerical mean of GPmax/D between the right and left femurs on an anterior image) exhibited the highest correlation coefficient (0.409) among the bone scintigraphy parameters (P = 0.034). The anterior GPmax/D also demonstrated a significant negative correlation with age (P = 0.042, correlation coefficient: -0.373). In a multiple regression analysis to predict growth velocity with adjusting for age and sex, the model that included left GPmean/D (geometric mean of GPmean/D between anterior and posterior images of the left femur) yielded the highest adjusted R2 value (0.786), followed by anterior GPmax/D (0.734).</p><p><strong>Conclusion: </strong>Quantitative growth plate uptake parameters on the distal femur in bone scintigraphy are significantly associated with growth velocity. These findings suggest that growth plate uptake in bone scintigraphy could potentially serve as a predictive marker of growth in children.</p>\",\"PeriodicalId\":19708,\"journal\":{\"name\":\"Nuclear Medicine Communications\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nuclear Medicine Communications\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/MNM.0000000000001992\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Medicine Communications","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MNM.0000000000001992","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Association of quantitative growth plate uptake parameters on bone scintigraphy with growth velocity in children.
Objective: The purpose of this study was to examine the association between quantitative growth plate uptake parameters in bone scintigraphy and growth velocity among children.
Methods: We conducted a retrospective analysis of 30 pediatric patients (21 male and nine female; age range, 3-15 years) who underwent planar bone scintigraphy. Ratios of maximum growth plate uptake to mean diaphyseal uptake (GPmax/D) and mean growth plate uptake to mean diaphyseal uptake (GPmean/D) were calculated for both femurs on anterior and posterior bone scintigraphy images. A total of eight GPmax/D parameters and eight GPmean/D parameters were measured. The relationships of growth plate uptake parameters with age and growth velocity (cm/year) were assessed.
Results: Correlation analysis with growth velocity revealed that the anterior GPmax/D (numerical mean of GPmax/D between the right and left femurs on an anterior image) exhibited the highest correlation coefficient (0.409) among the bone scintigraphy parameters (P = 0.034). The anterior GPmax/D also demonstrated a significant negative correlation with age (P = 0.042, correlation coefficient: -0.373). In a multiple regression analysis to predict growth velocity with adjusting for age and sex, the model that included left GPmean/D (geometric mean of GPmean/D between anterior and posterior images of the left femur) yielded the highest adjusted R2 value (0.786), followed by anterior GPmax/D (0.734).
Conclusion: Quantitative growth plate uptake parameters on the distal femur in bone scintigraphy are significantly associated with growth velocity. These findings suggest that growth plate uptake in bone scintigraphy could potentially serve as a predictive marker of growth in children.
期刊介绍:
Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.