Marius Wessinger, Nadine Gauchel, Daniel Strobel, Dawid L Staudacher, Tobias Wengenmayer, Constantin von Zur Mühlen, Hans-Jörg Busch, Katrin Fink, Katharina Müller-Peltzer, Fabian Bamberg, Klaus Kaier, Dirk Westermann, Christoph B Olivier
{"title":"超声辅助导管溶栓（USAT）治疗肺栓塞患者的技术成功和临床结果：一项回顾性单中心队列研究","authors":"Marius Wessinger, Nadine Gauchel, Daniel Strobel, Dawid L Staudacher, Tobias Wengenmayer, Constantin von Zur Mühlen, Hans-Jörg Busch, Katrin Fink, Katharina Müller-Peltzer, Fabian Bamberg, Klaus Kaier, Dirk Westermann, Christoph B Olivier","doi":"10.1007/s00392-025-02643-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Ultrasound-assisted catheter-directed thrombolysis (USAT) is a treatment option for patients with intermediate-high- or high-risk pulmonary embolism (PE). This study aimed to describe the use of USAT and its clinical outcomes.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, all USAT procedures performed between May 2019 and June 2022 were included. Data were collected from electronic health records. The primary outcome was reduction in right vs. left ventricular diameter (RV/LV ratio). Secondary outcomes were in-hospital mortality and bleeding.</p><p><strong>Results: </strong>A total of 107 patients underwent USAT for PE. The median age was 64 (IQR 53-75) years and 59% were male. Technical success of USAT was achieved in 105 (98%) cases. In 32 cases data on RV/LV ratio changes were available. RV/LV ratio decreased by 0.29 ± 0.19 from 1.19 (1.02-1.35) to 0.89 (0.78-1.00). 12 (11%) patients had a fatal outcome. Bleeding complications were observed in 28 (26%) patients, including 14 (13%) major bleedings and 0 (0%) fatal. Both, death and bleeding rates were significantly higher in high-risk patients.</p><p><strong>Conclusion: </strong>We observed a high technical success of USAT in patients with intermediate-high- and high-risk pulmonary embolism, along with a significant early reduction of RV/LV ratio following treatment.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characterizing technical success and clinical outcomes in patients with pulmonary embolism treated with ultrasound-assisted catheter-directed thrombolysis (USAT): a retrospective, single-center cohort study.\",\"authors\":\"Marius Wessinger, Nadine Gauchel, Daniel Strobel, Dawid L Staudacher, Tobias Wengenmayer, Constantin von Zur Mühlen, Hans-Jörg Busch, Katrin Fink, Katharina Müller-Peltzer, Fabian Bamberg, Klaus Kaier, Dirk Westermann, Christoph B Olivier\",\"doi\":\"10.1007/s00392-025-02643-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Ultrasound-assisted catheter-directed thrombolysis (USAT) is a treatment option for patients with intermediate-high- or high-risk pulmonary embolism (PE). This study aimed to describe the use of USAT and its clinical outcomes.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, all USAT procedures performed between May 2019 and June 2022 were included. Data were collected from electronic health records. The primary outcome was reduction in right vs. left ventricular diameter (RV/LV ratio). Secondary outcomes were in-hospital mortality and bleeding.</p><p><strong>Results: </strong>A total of 107 patients underwent USAT for PE. The median age was 64 (IQR 53-75) years and 59% were male. Technical success of USAT was achieved in 105 (98%) cases. In 32 cases data on RV/LV ratio changes were available. RV/LV ratio decreased by 0.29 ± 0.19 from 1.19 (1.02-1.35) to 0.89 (0.78-1.00). 12 (11%) patients had a fatal outcome. Bleeding complications were observed in 28 (26%) patients, including 14 (13%) major bleedings and 0 (0%) fatal. Both, death and bleeding rates were significantly higher in high-risk patients.</p><p><strong>Conclusion: </strong>We observed a high technical success of USAT in patients with intermediate-high- and high-risk pulmonary embolism, along with a significant early reduction of RV/LV ratio following treatment.</p>\",\"PeriodicalId\":10474,\"journal\":{\"name\":\"Clinical Research in Cardiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Research in Cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00392-025-02643-2\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Research in Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00392-025-02643-2","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Characterizing technical success and clinical outcomes in patients with pulmonary embolism treated with ultrasound-assisted catheter-directed thrombolysis (USAT): a retrospective, single-center cohort study.
Background: Ultrasound-assisted catheter-directed thrombolysis (USAT) is a treatment option for patients with intermediate-high- or high-risk pulmonary embolism (PE). This study aimed to describe the use of USAT and its clinical outcomes.
Methods: In this single-center retrospective cohort study, all USAT procedures performed between May 2019 and June 2022 were included. Data were collected from electronic health records. The primary outcome was reduction in right vs. left ventricular diameter (RV/LV ratio). Secondary outcomes were in-hospital mortality and bleeding.
Results: A total of 107 patients underwent USAT for PE. The median age was 64 (IQR 53-75) years and 59% were male. Technical success of USAT was achieved in 105 (98%) cases. In 32 cases data on RV/LV ratio changes were available. RV/LV ratio decreased by 0.29 ± 0.19 from 1.19 (1.02-1.35) to 0.89 (0.78-1.00). 12 (11%) patients had a fatal outcome. Bleeding complications were observed in 28 (26%) patients, including 14 (13%) major bleedings and 0 (0%) fatal. Both, death and bleeding rates were significantly higher in high-risk patients.
Conclusion: We observed a high technical success of USAT in patients with intermediate-high- and high-risk pulmonary embolism, along with a significant early reduction of RV/LV ratio following treatment.
期刊介绍：
Clinical Research in Cardiology is an international journal for clinical cardiovascular research. It provides a forum for original and review articles as well as critical perspective articles. Articles are only accepted if they meet stringent scientific standards and have undergone peer review. The journal regularly receives articles from the field of clinical cardiology, angiology, as well as heart and vascular surgery.
As the official journal of the German Cardiac Society, it gives a current and competent survey on the diagnosis and therapy of heart and vascular diseases.
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