Ziwei Zhang , Xiuxiu Zhou , Yi Xia , Qianxi Jin , Yu Guan , Taohu Zhou , Yueze Li , Shiyuan Liu , Li Fan
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Paired inspiratory and expiratory chest CT and pulmonary function tests (PFTs) were performed in all subjects, CT indices based on density and parametric response map (PRM) were obtained, and PFTs and CT data were retrospectively collected. The reference range was obtained with the Lambda-Mu-Sigma model. Independent-sample <em>t</em>-test/one-way ANOVA analysis or Mann-Whitney test/Kruskal-Wallis test were conducted to compare mean values between different groups. Spearman correlation analysis was used to evaluate the correlation between spirometric and CT quantitative indices.</div></div><div><h3>Results</h3><div>A total of 783 healthy subjects (255 men, 67 (63–69) years) were included. The reference ranges of lung volume, the percentage of low attenuation area (LAA (%)), PRM<sup>Emphy</sup> (%) and PRM<sup>fSAD</sup> (%) concerning age based on gender were established. LAA (%), PRM<sup>Emphy</sup> (%) and PRM<sup>fSAD</sup> (%) were significant higher in the upper lobes than in the lower lobes. There was a strong positive correlation between PRM<sup>Emphy</sup> (%) and PRM<sup>fSAD</sup> (%) (r = 0.62, p < 0.001).</div></div><div><h3>Conclusions</h3><div>We established Chinese reference ranges for CT quantitative indexes in the population aged from 40 to 75 years old.</div></div>","PeriodicalId":100921,"journal":{"name":"Meta-Radiology","volume":"3 2","pages":"Article 100154"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study\",\"authors\":\"Ziwei Zhang , Xiuxiu Zhou , Yi Xia , Qianxi Jin , Yu Guan , Taohu Zhou , Yueze Li , Shiyuan Liu , Li Fan\",\"doi\":\"10.1016/j.metrad.2025.100154\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>Computed tomography (CT) screening has established itself as the routine method to monitor lung conditions by providing pulmonary structural and functional information. 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引用次数: 0
摘要
目的计算机断层扫描（CT）通过提供肺结构和功能信息，已成为监测肺部状况的常规方法。然而，CT指标的参考范围仍然缺乏。因此，本研究旨在为中国健康中老年人群CT定量指标提供参考范围。方法入选我院接受NELCIN-B3方案治疗的中国健康成人783例。对所有受试者进行配对吸气、呼气胸部CT和肺功能测试（PFTs），获得基于密度和参数反应图（PRM）的CT指标，并回顾性收集PFTs和CT数据。参考范围采用Lambda-Mu-Sigma模型得到。采用独立样本t检验/单因素方差分析或Mann-Whitney检验/Kruskal-Wallis检验比较各组间均值。采用Spearman相关分析评价肺活量测定与CT定量指标的相关性。结果共纳入健康受试者783例，其中男性255例，年龄67（63 ~ 69）岁。建立肺体积、低衰减面积百分比（LAA(%)）、PRMEmphy（%）、PRMfSAD（%）与年龄相关的性别参考范围。LAA（%）、PRMEmphy（%）和PRMfSAD（%）在上叶明显高于下叶。PRMEmphy（%）与PRMfSAD（%）呈正相关(r = 0.62, p <；0.001)。结论建立了40 ~ 75岁人群CT定量指标的中文参考范围。
Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study
Purpose
Computed tomography (CT) screening has established itself as the routine method to monitor lung conditions by providing pulmonary structural and functional information. However, the reference ranges of CT indices are still lacking. Therefore, this study aimed to provide reference ranges for CT quantitative indexes in healthy middle-aged and elderly Chinese population.
Methods
A total of 783 healthy Chinese adults attending our hospital for the NELCIN-B3 protocol were enrolled. Paired inspiratory and expiratory chest CT and pulmonary function tests (PFTs) were performed in all subjects, CT indices based on density and parametric response map (PRM) were obtained, and PFTs and CT data were retrospectively collected. The reference range was obtained with the Lambda-Mu-Sigma model. Independent-sample t-test/one-way ANOVA analysis or Mann-Whitney test/Kruskal-Wallis test were conducted to compare mean values between different groups. Spearman correlation analysis was used to evaluate the correlation between spirometric and CT quantitative indices.
Results
A total of 783 healthy subjects (255 men, 67 (63–69) years) were included. The reference ranges of lung volume, the percentage of low attenuation area (LAA (%)), PRMEmphy (%) and PRMfSAD (%) concerning age based on gender were established. LAA (%), PRMEmphy (%) and PRMfSAD (%) were significant higher in the upper lobes than in the lower lobes. There was a strong positive correlation between PRMEmphy (%) and PRMfSAD (%) (r = 0.62, p < 0.001).
Conclusions
We established Chinese reference ranges for CT quantitative indexes in the population aged from 40 to 75 years old.
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