HIF-1、HO-1、GLUT-1和GLUT-4在心肌保护中的作用

Lionel Chong, Nicholas Dushaj, Ani Rakoubian, Johnathan Yarbro, Satoru Kobayashi, Qiangrong Liang
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引用次数: 0

摘要

心肌细胞高度依赖氧气来实现最佳功能。在缺血性心脏病的情况下,氧气供应的中断可以显著损害心脏功能。此外,糖尿病、高脂血症和高血压等合并症可加重缺血性心脏损伤。然而,在这种情况下,心肌细胞具有内在的保护机制,可以激活以提高心肌存活。了解这些心脏保护基因的功能和调控机制对于提高我们对心血管健康的认识和制定治疗策略至关重要。本文综述了心脏保护的复杂机制,重点关注关键基因和蛋白,包括缺氧诱导因子-1 (HIF-1)、血红素加氧酶-1 (HO-1)、葡萄糖转运蛋白1 (GLUT-1)和GLUT-4。此外,本文还探讨了这些因子在缺血应激下心脏的作用和调控,揭示了它们在糖尿病、高血压、高脂血症/动脉粥样硬化等疾病中的相关性。此外,它强调了它们之间复杂的相互作用机制,并为开发缺血性心脏病、高血压和高脂血症的靶向治疗提供了机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unraveling the Roles of HIF-1, HO-1, GLUT-1 and GLUT-4 in Myocardial Protection.

Cardiomyocytes are highly dependent on oxygen for optimal function. Disruption of oxygen availability, as in the case of ischemic heart disease, can significantly impair heart function. Moreover, comorbidities like diabetes, hyperlipidemia, and hypertension can exacerbate ischemic cardiac injury. However, cardiomyocytes possess inherent protective mechanisms that can be activated to enhance myocardial survival under such conditions. Understanding the functions and regulatory mechanisms of these cardioprotective genes is crucial for advancing our knowledge of cardiovascular health and for developing therapeutic strategies. This review examines the intricate mechanisms of cardioprotection, with a focus on key genes and proteins, including hypoxia-inducible factor-1 (HIF-1), heme oxygenase-1 (HO-1), glucose transporter 1 (GLUT-1), and GLUT-4. In addition, the review explores the roles and regulation of these factors in the heart under ischemic stress, shedding light on their relevance in conditions like diabetes, hypertension, and hyperlipidemia/atherosclerosis. Moreover, it highlights the complex interplay among their mechanisms and suggests opportunities for developing targeted therapiesfor the treatment of ischemic heart disease, hypertension, and hyperlipidemia.

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