Hannes Leupe, Niloefar Ahmadi Bidakhvidi, Karolien Goffin, Bliede Van den Broeck, Sander Jentjens, Annouschka Laenen, Elin Pauwels, Willem Lybaert, Eric Van Cutsem, Guy Bormans, Timon Vandamme, Frederik Cleeren, Jeroen Dekervel, Karen Geboes, Sigrid Stroobants, Chris Verslype, Christophe M Deroose
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Five readers assessed lesion detection and characterization across multiple organs, scoring lesions by number and conspicuity using a 5-point Likert scale. Agreement was measured using Gwet's agreement coefficient.</p><p><strong>Results: </strong>Results demonstrated nearly perfect interobserver agreement for lesion characterization across all organs for both tracers (0.921 for [<sup>18</sup>F]AlF-OC; 0.934 for [<sup>68</sup>Ga]Ga-DOTA-SSA). Similar agreement was observed for the number of lesions across organs (0.736 for [<sup>18</sup>F]AlF-OC and 0.749 for [<sup>68</sup>Ga]Ga-DOTA-SSAs). Organ-specific analysis revealed strong agreement for bone and liver lesions, with slightly lower agreement for lymph nodes. Both tracers also showed excellent agreement in determining Krenning scores (0.925 for [<sup>18</sup>F]AlF-OC and 0.927 for [<sup>68</sup>Ga]Ga-DOTA-SSAs). While mean lesion conspicuity was similar between tracers, [<sup>18</sup>F]AlF-OC had a higher global image quality score (4.22 vs. 3.86, p < 0.0001). Intraobserver agreement was consistent between tracers for lesion characterization (> 0.95 for both readers) and lesion count (> 0.80 for both readers).</p><p><strong>Conclusion: </strong>[<sup>18</sup>F]AlF-OC and [<sup>68</sup>Ga]Ga-DOTA-SSAs demonstrate comparable and excellent inter- and intraobserver agreement, reinforcing the clinical interchangeability of [<sup>18</sup>F]AlF-OC PET/CT with [<sup>68</sup>Ga]Ga-DOTA-SSAs in routine practice.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"9 1","pages":"17"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078903/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparison of inter- and intraobserver agreement between [<sup>18</sup>F]AlF-NOTA-octreotide and [<sup>68</sup>Ga]Ga-DOTA-SSA PET/CT.\",\"authors\":\"Hannes Leupe, Niloefar Ahmadi Bidakhvidi, Karolien Goffin, Bliede Van den Broeck, Sander Jentjens, Annouschka Laenen, Elin Pauwels, Willem Lybaert, Eric Van Cutsem, Guy Bormans, Timon Vandamme, Frederik Cleeren, Jeroen Dekervel, Karen Geboes, Sigrid Stroobants, Chris Verslype, Christophe M Deroose\",\"doi\":\"10.1186/s41824-025-00250-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study compares inter- and intraobserver agreement between [<sup>18</sup>F]AlF-NOTA-octreotide ([<sup>18</sup>F]AlF-OC) and [<sup>68</sup>Ga]Ga-DOTA-somatostatin analogues (SSAs) in PET/CT imaging for neuroendocrine neoplasm (NEN) patients.</p><p><strong>Materials and methods: </strong>This is a secondary endpoint analysis from our multicenter trial (clin trial.gov identifier: NCT04552847) including 75 NEN patients who received both [<sup>68</sup>Ga]Ga-DOTATATE (n = 56) or [<sup>68</sup>Ga]Ga-DOTA-NOC (n = 19) and [<sup>18</sup>F]AlF-OC PET imaging. Five readers assessed lesion detection and characterization across multiple organs, scoring lesions by number and conspicuity using a 5-point Likert scale. Agreement was measured using Gwet's agreement coefficient.</p><p><strong>Results: </strong>Results demonstrated nearly perfect interobserver agreement for lesion characterization across all organs for both tracers (0.921 for [<sup>18</sup>F]AlF-OC; 0.934 for [<sup>68</sup>Ga]Ga-DOTA-SSA). Similar agreement was observed for the number of lesions across organs (0.736 for [<sup>18</sup>F]AlF-OC and 0.749 for [<sup>68</sup>Ga]Ga-DOTA-SSAs). Organ-specific analysis revealed strong agreement for bone and liver lesions, with slightly lower agreement for lymph nodes. Both tracers also showed excellent agreement in determining Krenning scores (0.925 for [<sup>18</sup>F]AlF-OC and 0.927 for [<sup>68</sup>Ga]Ga-DOTA-SSAs). While mean lesion conspicuity was similar between tracers, [<sup>18</sup>F]AlF-OC had a higher global image quality score (4.22 vs. 3.86, p < 0.0001). Intraobserver agreement was consistent between tracers for lesion characterization (> 0.95 for both readers) and lesion count (> 0.80 for both readers).</p><p><strong>Conclusion: </strong>[<sup>18</sup>F]AlF-OC and [<sup>68</sup>Ga]Ga-DOTA-SSAs demonstrate comparable and excellent inter- and intraobserver agreement, reinforcing the clinical interchangeability of [<sup>18</sup>F]AlF-OC PET/CT with [<sup>68</sup>Ga]Ga-DOTA-SSAs in routine practice.</p>\",\"PeriodicalId\":519909,\"journal\":{\"name\":\"EJNMMI reports\",\"volume\":\"9 1\",\"pages\":\"17\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078903/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJNMMI reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s41824-025-00250-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJNMMI reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s41824-025-00250-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的：本研究比较了[18F] alf - nota -奥曲肽（[18F]AlF-OC）和[68Ga] ga - dota -生长抑素类似物（SSAs）在神经内分泌肿瘤（NEN）患者PET/CT成像中的一致性。材料和方法：这是一项来自我们的多中心试验（临床试验。gov标识符：NCT04552847）的次要终点分析，包括75名NEN患者，他们接受了[68Ga]Ga-DOTATATE （n = 56）或[68Ga]Ga-DOTA-NOC （n = 19）和[18F]AlF-OC PET成像。五名读者评估了跨多个器官的病变检测和特征，使用5分李克特量表根据数量和显著性对病变进行评分。使用Gwet的一致系数来衡量一致性。结果：结果显示两种示踪剂在所有器官的病变特征上几乎完全一致(0.921:[18F]AlF-OC；[68Ga]Ga-DOTA-SSA) 0.934。跨器官的病变数量也相似（[18F]AlF-OC为0.736，[68Ga]Ga-DOTA-SSAs为0.749）。器官特异性分析显示骨骼和肝脏病变有很强的一致性，淋巴结的一致性稍低。两种示踪剂在测定Krenning评分时也表现出极好的一致性（[18F]AlF-OC为0.925，[68Ga]Ga-DOTA-SSAs为0.927）。虽然两种示踪剂的平均病变显著性相似，但[18F]AlF-OC具有更高的全局图像质量评分（4.22比3.86，两种读取器p 0.95）和病变计数（> 0.80）。结论：[18F]AlF-OC和[68Ga]Ga-DOTA-SSAs在观察间和观察内表现出相当的一致性，增强了[18F]AlF-OC PET/CT与[68Ga]Ga-DOTA-SSAs的临床互换性。
Comparison of inter- and intraobserver agreement between [18F]AlF-NOTA-octreotide and [68Ga]Ga-DOTA-SSA PET/CT.
Purpose: This study compares inter- and intraobserver agreement between [18F]AlF-NOTA-octreotide ([18F]AlF-OC) and [68Ga]Ga-DOTA-somatostatin analogues (SSAs) in PET/CT imaging for neuroendocrine neoplasm (NEN) patients.
Materials and methods: This is a secondary endpoint analysis from our multicenter trial (clin trial.gov identifier: NCT04552847) including 75 NEN patients who received both [68Ga]Ga-DOTATATE (n = 56) or [68Ga]Ga-DOTA-NOC (n = 19) and [18F]AlF-OC PET imaging. Five readers assessed lesion detection and characterization across multiple organs, scoring lesions by number and conspicuity using a 5-point Likert scale. Agreement was measured using Gwet's agreement coefficient.
Results: Results demonstrated nearly perfect interobserver agreement for lesion characterization across all organs for both tracers (0.921 for [18F]AlF-OC; 0.934 for [68Ga]Ga-DOTA-SSA). Similar agreement was observed for the number of lesions across organs (0.736 for [18F]AlF-OC and 0.749 for [68Ga]Ga-DOTA-SSAs). Organ-specific analysis revealed strong agreement for bone and liver lesions, with slightly lower agreement for lymph nodes. Both tracers also showed excellent agreement in determining Krenning scores (0.925 for [18F]AlF-OC and 0.927 for [68Ga]Ga-DOTA-SSAs). While mean lesion conspicuity was similar between tracers, [18F]AlF-OC had a higher global image quality score (4.22 vs. 3.86, p < 0.0001). Intraobserver agreement was consistent between tracers for lesion characterization (> 0.95 for both readers) and lesion count (> 0.80 for both readers).
Conclusion: [18F]AlF-OC and [68Ga]Ga-DOTA-SSAs demonstrate comparable and excellent inter- and intraobserver agreement, reinforcing the clinical interchangeability of [18F]AlF-OC PET/CT with [68Ga]Ga-DOTA-SSAs in routine practice.
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