JAK-STAT信号在自身免疫和癌症中的作用。

IF 6.2 Q1 IMMUNOLOGY
ImmunoTargets and Therapy Pub Date : 2025-05-11 eCollection Date: 2025-01-01 DOI:10.2147/ITT.S485670
Sana Parveen, Mariyam Fatma, Snober Shabnam Mir, Said Dermime, Shahab Uddin
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引用次数: 0

摘要

JAK-STAT通路是调节炎症、免疫和癌症相关基因表达的重要细胞生存信号。细胞因子受体、信号转导和转录激活因子(STAT)蛋白和Janus激酶(JAKs)是这一信号级联的关键组成部分。当jak受到细胞因子的刺激时,会发生STAT磷酸化、二聚化和核易位,最终影响基因转录。JAK-STAT信号的失调与多种自身免疫性疾病有关,包括类风湿关节炎、牛皮癣和炎症性肠病。这一途径在人类恶性肿瘤中被组成性激活,导致肿瘤细胞存活、增殖和免疫逃避。在实体瘤、白血病和淋巴瘤中发现了JAK和STAT基因的致癌突变。靶向JAK-STAT通路是治疗自身免疫性疾病和癌症的一种可行且有前景的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
JAK-STAT Signaling in Autoimmunity and Cancer.

The JAK-STAT pathway is an essential cell survival signaling that regulates gene expressions related to inflammation, immunity and cancer. Cytokine receptors, signal transducer and activator of transcription (STAT) proteins, and Janus kinases (JAKs) are the critical component of this signaling cascade. When JAKs are stimulated by cytokines, STAT phosphorylation, dimerization, and nuclear translocation occur, which eventually impacts gene transcription. Dysregulation of JAK-STAT signaling is linked with various autoimmune diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. This pathway is constitutively activated in human malignancies and leads to tumor cell survival, proliferation, and immune evasion. Oncogenic mutations in the JAK and STAT genes have been found in solid tumors, leukemia, and lymphoma. Targeting the JAK-STAT pathway is a viable and promising therapeutic strategy for the treatment of autoimmune diseases and cancers.

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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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