Comparison of prognostic value of triglyceride-glucose index and atherogenic index of plasma in patients with acute coronary syndrome: A retrospective study.

Objective: Few studies have compared the prognostic value of the triglyceride glucose (TyG) index and atherogenic index of plasma (AIP) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). We aimed to compare the prognostic value of the TyG index, AIP, and combined diagnosis in patients with ACS undergoing PCI.

Methods: Patients with ACS who underwent PCI were enrolled and divided into two groups according to major adverse cardiovascular and cerebrovascular events (MACCEs). Univariate and multivariate Cox proportional hazard regressions were performed to determine independent risk factors for MACCEs. The area under the receiver operating characteristic curve (AUC) was used to evaluate the diagnostic value of the TyG index, AIP, and combined prediction.

Results: The study included 114 patients. Multivariate Cox regression revealed that the TyG index and AIP were independent predictors of MACCEs. The AUC of the TyG index and AIP were 0.710 (95% confidence interval [CI]: 0.618-0.791) and 0.626 (95% CI: 0.531-0.715), respectively, and the optimal cutoff points were 8.83 and 0.30, respectively. The difference between the TyG index and AIP was not significant. The AUC of the combined diagnosis was 0.706 (95% CI: 0.614-0.788), with no significant improvement compared with the TyG index or AIP.

Conclusion: Both the TyG index and AIP were independent predictors of MACCEs in ACS patients undergoing PCI. The TyG index and AIP had similar predictive values for MACCEs, but the combined prediction did not improve significantly.