GPT-PPG: a GPT-based foundation model for photoplethysmography signals.

Objective. This study aims to introduce a novel generative pre-trained transformer (GPT)-based foundation model specifically tailored to photoplethysmography (PPG) signals, enabling effective adaptation to various downstream biomedical tasks.Approach. We adapted the standard GPT architecture to handle the continuous characteristics of PPG signals, leveraging extensive pre-training on a large dataset comprising over 200 million 30 s PPG samples, followed by supervised fine-tuning strategies for task-specific optimization.Main results. Our approach achieves performance comparable to or exceeding current state-of-the-art methods on various downstream tasks, notably atrial fibrillation detection, and demonstrates a unique generative capability, such as effective signal denoising, inherently available without additional fine-tuning.Significance. The successful adaptation of GPT to PPG signals underscores the potential of generative transformer frameworks as versatile foundation models in biomedical signal processing, highlighting their dual role in predictive and generative tasks.