三种复合炎症和脂质代谢指标与心血管-肾-代谢综合征的关联:基于NHANES 1999-2020的横断面研究

IF 4.4 3区 医学 Q2 CELL BIOLOGY
Mediators of Inflammation Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI:10.1155/mi/6691516
Jiayuan Song, Ziyi Xu, Han Yu, Aimin Li, Yiying Liu, Meiying Jin
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引用次数: 0

摘要

背景:各种白细胞与高密度脂蛋白胆固醇(HDL-C)比率,即中性粒细胞与HDL-C比率(NHR)、淋巴细胞与HDL-C比率(LHR)和单核细胞与HDL-C比率(MHR),已被确定为潜在的炎症生物标志物。尽管如此,这些比率与心血管-肾脏-代谢(CKM)综合征之间的复杂关系尚未完全阐明。本研究旨在探讨这些白细胞比例与CKM综合征存在之间的关系。方法:这项横断面回顾性分析利用了1999-2020年国家健康与营养检查调查(NHANES)数据库中19534名CKM综合征确诊患者的数据。对参与者进行分层,并在分析过程中调整相关协变量。采用加权logistic回归模型,以0期为参考点,统计评估炎症标志物与CKM综合征不同分期之间的关系。结果:在对所有协变量进行调整后,以0期为参考,高水平的三种炎症指标与1-4期CKM综合征的高发生率相关。当我们以0-1-2期为参照组评估炎症指标与3-4期之间的关系时,我们发现炎症指标仍然增加了CKM综合征分期较高的风险。剂量-反应关系显示炎症指标增加CKM综合征分期升高的风险。在进行亚组分析后,我们发现LHR和教育,以及LHR、MHR和饮酒状况有显著的相互作用。结论:NHR、LHR和MHR升高与1-4期CKM综合征风险增加显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Three Composite Inflammatory and Lipid Metabolism Indicators With Cardiovascular-Kidney-Metabolic Syndrome: A Cross-Sectional Study Based on NHANES 1999-2020.

Background: Various leukocyte-to-high-density lipoprotein cholesterol (HDL-C) ratios, namely the neutrophil to HDL-C ratio (NHR), lymphocyte to HDL-C ratio (LHR), and monocyte to HDL-C ratio (MHR), have been identified as potential inflammatory biomarkers. Despite this, the intricate relationship between these ratios and Cardiovascular-Kidney-Metabolic (CKM) Syndrome has yet to be fully elucidated. This study aims to explore the associations between these white blood cell ratios and the presence of CKM Syndrome. Methods: This cross-sectional retrospective analysis utilized data from 19,534 individuals diagnosed with CKM Syndrome, sourced from the National Health and Nutrition Examination Survey (NHANES) database covering the years 1999-2020. Participants were stratified, and relevant covariates were adjusted during the analysis. Weighted logistic regression models were employed to statistically assess the relationships between the inflammatory markers and the differing stages of CKM Syndrome, with stage 0 serving as the reference point. Results: After adjusting for all the covariates, high levels of three inflammatory indicators were associated with higher odds of having CKM Syndrome stage 1-4, using stage 0 as a reference. When we assessed the associations between inflammatory indicators with stage 3-4 with stage 0-1-2 as the reference group, we found that inflammatory indicators still increased the risk of higher CKM Syndrome stage. The dose-response relationship revealed that the inflammatory indicators increased the risk of higher CKM Syndrome stage. After conducting subgroup analyses, we found that LHR and education, as well as LHR, MHR, and drinking status, had significant interactions. Conclusion: Elevated NHR, LHR, and MHR are significantly associated with an increased risk of CKM Syndrome across stages 1-4.

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来源期刊
Mediators of Inflammation
Mediators of Inflammation 医学-免疫学
CiteScore
8.70
自引率
0.00%
发文量
202
审稿时长
4 months
期刊介绍: Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
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