神经内分泌肿瘤的代谢变化。

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cellular and Molecular Life Sciences Pub Date : 2025-05-16 DOI:10.1007/s00018-025-05656-2

Chunhua Hu, Lingyi Chen, Yi Ding, Mujie Ye, Qiyun Tang

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引用次数: 0

摘要

神经内分泌肿瘤（NENs）是一组起源于神经内分泌细胞的高度异质性肿瘤，其发病率逐渐增加。代谢变化是公认的肿瘤进展标志物之一，在其他恶性肿瘤中已得到广泛而系统的研究。然而，对NENs代谢变化的研究相对较少，缺乏系统综述。我们从糖代谢、脂代谢、代谢综合征、氨基酸代谢和代谢组学等方面综述了代谢变化与NENs的关系，并探讨了代谢变化对NENs的潜在治疗策略。

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Metabolic changes in neuroendocrine neoplasms.

Neuroendocrine neoplasms (NENs) are a group of highly heterogeneous neoplasms originating from neuroendocrine cells with a gradually increased incidence. Metabolic change is one of the recognized markers of tumor progression, which has been extensively and systematically studied in other malignant tumors. However, metabolic change in NENs has been relatively poorly studied, and systematic reviews are lacking. We reviewed the relationship between metabolic changes and NENs from the aspects of glucose metabolism, lipid metabolism, metabolic syndrome, amino acid metabolism and metabolomics, and discussed the potential therapeutic strategies of metabolic changes for NENs.

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来源期刊

Cellular and Molecular Life Sciences 生物-生化与分子生物学

CiteScore

13.20

自引率

1.20%

发文量

546

审稿时长

1.0 months

期刊介绍： Journal Name: Cellular and Molecular Life Sciences (CMLS) Location: Basel, Switzerland Focus: Multidisciplinary journal Publishes research articles, reviews, multi-author reviews, and visions & reflections articles Coverage: Latest aspects of biological and biomedical research Areas include: Biochemistry and molecular biology Cell biology Molecular and cellular aspects of biomedicine Neuroscience Pharmacology Immunology Additional Features: Welcomes comments on any article published in CMLS Accepts suggestions for topics to be covered