非小细胞肺癌的内质网应激。

IF 3.6 3区医学 Q2 ONCOLOGY

American journal of cancer research Pub Date : 2025-04-25 eCollection Date: 2025-01-01 DOI:10.62347/RGRQ7608

Xiaodong Li, Fangning Hu, Tong Lu, Shuo Wu, Guanqiang Ma, Yani Lin, Hua Zhang

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引用次数: 0

摘要

内质网（ER）是一种存在于各种真核细胞中的细胞器，负责蛋白质的合成、修饰、折叠和运输，以及脂质代谢和Ca2+稳态的调节。内质网应激在非小细胞肺癌（NSCLC）的发病和治疗反应中起着关键作用，通过其独特的感知和调控机制显著影响细胞命运的决定。本文旨在阐明内质网应激传感器的关键作用，并探讨它们如何在药物治疗的非小细胞肺癌中介导细胞自噬、凋亡和非凋亡模式的细胞死亡。本研究为优化未来非小细胞肺癌的治疗策略奠定了坚实的基础。

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Endoplasmic reticulum stress in non-small cell lung cancer.

The Endoplasmic reticulum (ER), an organelle present in various eukaryotic cells, is responsible for protein synthesis, modification, folding, and transport, as well as for the regulation of lipid metabolism and Ca²⁺ homeostasis. ER stress plays a pivotal role in the pathogenesis and therapeutic response of non-small cell lung cancer (NSCLC), significantly influencing cellular fate decisions through its unique sensing and regulatory mechanisms. This review aims to elucidate the key role of ER stress sensors and to explore how they mediate cell autophagy, apoptosis, and non-apoptotic modes of cell death in the context of drug-treated NSCLC. This investigation lays a solid foundation for optimizing future treatment strategies for NSCLC.

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来源期刊

American journal of cancer research ONCOLOGY-

自引率

3.80%

发文量

263

期刊介绍： The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.