弥合THC知识差距，促进道路安全：行动呼吁。

IF 5.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Clinical Pharmacology & Therapeutics Pub Date : 2025-05-15 DOI:10.1002/cpt.3717

Peizhi Li, Guohua An

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引用次数: 0

摘要

吸食大麻后驾车的案例越来越多，这是一个迫在眉睫的公共安全问题，目前各州通过不同的法规来解决这个问题。然而，这些规则尚未得到验证，缺乏科学的稳健性。其中一个阻碍因素是由于有限的临床数据，我们对四氢大麻酚的药代动力学（PK）和药效学（PD）的了解不足。因此，我们呼吁研究人员和政策制定者共同努力，开展更全面的大麻PK/PD研究，以改进和验证现有的大麻驾驶法规。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bridging THC Knowledge Gaps for Safer Roads: A Call for Action

The rising cases of cannabis-impaired driving present a looming public safety concern that's currently addressed through varying state regulations. However, these regulations are yet validated and lack scientific robustness. One of the roadblocking factors is our insufficient understanding of THC's pharmacokinetics (PK) and pharmacodynamics (PD) due to limited clinical data. Therefore, we call for joint efforts among researchers and policymakers to conduct more comprehensive cannabis PK/PD studies to improve and validate existing cannabis driving regulations.

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来源期刊

Clinical Pharmacology & Therapeutics 医学-药学

CiteScore

12.70

自引率

7.50%

发文量

290

审稿时长

2 months

期刊介绍： Clinical Pharmacology & Therapeutics (CPT) is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics. CPT welcomes original Articles in the emerging areas of translational, predictive and personalized medicine; new therapeutic modalities including gene and cell therapies; pharmacogenomics, proteomics and metabolomics; bioinformation and applied systems biology complementing areas of pharmacokinetics and pharmacodynamics, human investigation and clinical trials, pharmacovigilence, pharmacoepidemiology, pharmacometrics, and population pharmacology.