异淀粉基取代酞菁配合物：合成、增溶及体外光动力活性

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-05-10 DOI:10.1016/j.ica.2025.122748

Elena A. Gorbunova , Nikita E. Kononenko , Alina S. Agranat , Anastasia A. Antonets , Andrey V. Sybachin , Dmitry N. Gorbunov , Alexander A. Guda , Tatiana V. Dubinina , Elena R. Milaeva

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引用次数: 0

摘要

以4,5-二（异淀粉基）邻苯二腈为起始原料，合成了以锌（II）、镁（II）和镥（III）为中心离子的新型光敏剂异淀粉基取代酞菁配合物。发现了以市售邻苯二酚为原料制备4,5-二（异戊氧基）邻苯二腈的有效方法。异淀粉基取代酞菁配合物显示出产生活性氧和荧光的能力。为了获得酞菁的水溶性形式，β-环糊精被用于将生物活性货物运送到目标区域。锌（II）配合物的水溶性形式在体外表现出明显的光动力学活性，与氯e6相当。

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Isoamyloxy-substituted phthalocyanine complexes: Synthesis, solubilization and in vitro photodynamic activity

Novel photosensitizers, isoamyloxy-substituted phthalocyanine complexes containing zinc(II), magnesium(II) and lutetium(III) as central ions, were synthesized by developing a synthetic procedure starting from 4,5-bis(isoamyloxy)phthalonitrile. Effective approaches were found to obtain 4,5-bis(isoamyloxy)phthalonitrile based on commercially available pyrocatechol. Isoamyloxy-substituted phthalocyanine complexes demonstrated ability to generate reactive oxygen species and fluoresce. To obtain water-soluble forms of phthalocyanines - β-cyclodextrin was used for the delivery of bioactive cargo to the target area. The water-soluble form of the zinc(II) complex exhibited pronounced photodynamic activity in vitro, comparable to chlorin e6.

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.