Elena A. Gorbunova , Nikita E. Kononenko , Alina S. Agranat , Anastasia A. Antonets , Andrey V. Sybachin , Dmitry N. Gorbunov , Alexander A. Guda , Tatiana V. Dubinina , Elena R. Milaeva
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Isoamyloxy-substituted phthalocyanine complexes: Synthesis, solubilization and in vitro photodynamic activity
Novel photosensitizers, isoamyloxy-substituted phthalocyanine complexes containing zinc(II), magnesium(II) and lutetium(III) as central ions, were synthesized by developing a synthetic procedure starting from 4,5-bis(isoamyloxy)phthalonitrile. Effective approaches were found to obtain 4,5-bis(isoamyloxy)phthalonitrile based on commercially available pyrocatechol. Isoamyloxy-substituted phthalocyanine complexes demonstrated ability to generate reactive oxygen species and fluoresce. To obtain water-soluble forms of phthalocyanines - β-cyclodextrin was used for the delivery of bioactive cargo to the target area. The water-soluble form of the zinc(II) complex exhibited pronounced photodynamic activity in vitro, comparable to chlorin e6.
期刊介绍:
Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews.
Topics covered include:
• chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies;
• synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs);
• reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models;
• applications of inorganic compounds, metallodrugs and molecule-based materials.
Papers composed primarily of structural reports will typically not be considered for publication.