钯催化硫醚-环丙烯硫羰基化制备羰基化双官能化环丙烯的高收敛模块化途径。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-16 DOI:10.1021/acs.orglett.5c01709

Xuening Li,Suliang Wang,Jian Song,Xianjie Fang

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引用次数: 0

摘要

钯催化环丙烯与有机二硫化物的硫醚-硫代羰基化合成了羰基化二官能化环丙烯的新方法。初步研究表明，有机二硫化物中的富电子单元更有利于硫酯的生成。该工艺适用于一系列环丙烷衍生物，并采用市售的二硫化物作为合作伙伴。值得注意的是，克级反应和进一步的转化证明了这种方法在有机合成中的实用性和应用潜力。

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Highly Convergent Modular Access to Carbonylative Difunctionalized Cyclopropanes via Palladium-Catalyzed Thioether-Thiocarbonylation of Cyclopropenes.

A novel and efficient synthesis of carbonylative difunctionalized cyclopropanes was disclosed by the palladium-catalyzed thioether-thiocarbonylation of cyclopropenes with organic disulfides. Preliminary studies show that the electron-rich unit in organic disulfide was more conducive to the production of the thioesters. This process is applicable to a series of cyclopropane derivatives and employs commercially available diaryl disulfides as the partners. Notably, the gram-scale reaction and further transformations demonstrate the practicality and application potential of this approach for organic synthesis.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.