研究瑞香素的治疗潜力和分子机制:综述。

Linyue Zhang, Jingwu Wu, Jinzhenwan Xue, Zhihong Jia, Xiaoni Zhou, Gang Hu
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摘要

香豆素是一种普遍存在于多种生物中的芳香化合物,包括细菌、真菌和150多种植物,多年来一直被广泛研究。研究人员已经分离并鉴定了1300多种天然香豆素,其中许多具有很好的生物医学特性。其中,瑞香素是一种独特的香豆素衍生物,其独特的结构特征赋予了特殊的物理化学性质。瑞香素以其多种生物活性而闻名,包括抗癌、抗炎和抗过敏作用。这些活性可归因于其调节体内特定分子途径的能力,使其成为药理学研究中极具吸引力的化合物。因此,瑞香素在科学界引起了相当大的关注,特别是促使人们对其在不同临床条件下的治疗潜力进行了广泛的调查。在这篇综合综述中,我们深入研究了瑞香素的结构和来源,重点介绍了其独特的特性,强调了其作为治疗剂的潜力。我们进一步探讨了瑞香素的治疗潜力,强调了其多方面的生物活性和潜在的分子机制。此外,结合目前的研究现状和该方向的研究前景,对瑞香素的潜在毒性作用进行了探讨。通过强调瑞香素的临床意义,我们的目标是为一系列疾病的创新和有效治疗策略的发展做出贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the Therapeutic Potential and Molecular Mechanisms of Daphnetin: A Comprehensive Review.

Coumarins, a ubiquitous class of aromatic compounds present in a broad spectrum of organisms, including bacteria, fungi, and over 150 plant species, have been extensively studied over the years. Researchers have isolated and characterized more than 1,300 natural coumarins, many of which exhibit promising biomedical properties. Among these, daphnetin has emerged as a distinctive coumarin derivative that is characterized by its unique structural features to impart special physicochemical attributes. Daphnetin is renowned for its diverse range of biological activities, encompassing anticancer, anti-inflammatory, and antiallergic effects. These activities can be attributed to its ability to regulate specific molecular pathways within the body, making it a highly attractive compound for pharmacological research. Consequently, daphnetin has garnered considerable attention within the scientific community, specifically prompting an extensive investigation into its therapeutic potential across diverse clinical conditions. In this comprehensive review, we delved into the structure and sources of daphnetin, with a focus on its unique characteristics that underscore its potential as a therapeutic agent. We further explored the therapeutic potential of daphnetin, highlighting its multifaceted biological activities and the underlying molecular mechanisms. In addition, we scrutinized the potentially toxic effects of daphnetin in light of the current research status and prospects in this direction. By emphasizing the clinical significance of daphnetin, we aim to contribute to the ongoing endeavors toward the development of innovative and efficacious therapeutic strategies for an array of diseases.

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