阐明Nrf2信号通路在支原体感染中的作用。

IF 3.3 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova, Ekaterina Neborak, Natallia Zhabo
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引用次数: 0

摘要

支原体是最小的无细胞壁自我复制的原核生物。支原体可以在细胞内外被发现,作为“沉默的寄生虫”生活在细胞内和膜表面寄生虫。病原体对呼吸系统健康的影响似乎主要是由于其改变免疫反应、引起气道炎症和破坏上皮屏障的能力。在了解支原体诱导的炎症和氧化应激方面取得了很大进展。然而,在治疗管理方面仍然存在一些问题,例如对抗生素耐药菌株的发展,现有诊断技术的缺点以及可能的长期呼吸后果。另一方面,为了对抗氧化应激、炎症和代谢异常,激活转录因子核因子-红细胞2相关因子2 (Nrf2)正成为一种更有吸引力的治疗策略。Nrf2激活通过其转录靶标协调彻底的防御,使其能够在各种细胞应激源下适应和生存。Nrf2被认为是治疗靶点,药理Nrf2激活剂在多种病理后果中显示出保护作用,在临床试验中具有优势。在这篇综述中,我们讨论了在支原体引起的一系列炎症反应中靶向Nrf2的基本原理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Elucidating the Role of Nrf2 Signaling Pathway in Mycoplasma Infections.

Mycoplasmas are the smallest cell-wall-less self-replicating prokaryotes. Mycoplasma species can be found within and outside cells as "silent parasites" that live intracellularly and as membrane surface parasites. The pathogen's impact on respiratory health seems primarily caused by its capacity to alter immune responses, cause airway inflammation, and damage epithelial barriers. Much progress has been made in understanding Mycoplasma-induced inflammation and oxidative stress. However, there are still issues in therapeutic management, such as the development of strains that are resistant to antibiotics, the shortcomings of the available diagnostic techniques, and possible long-term respiratory consequences. On the other hand, to combat oxidative stress, inflammation, and metabolic abnormalities, activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is becoming a more appealing therapeutic strategy. Nrf2 activation coordinates a thorough defense through its transcriptional targets, enabling adaptability and survival under a variety of cellular stressors. Nrf2 is regarded as a therapeutic target, and pharmacological Nrf2 activators have demonstrated protective effects in multiple pathological consequences and advantages in clinical trials. In this review, we discussed the rationale for targeting Nrf2 in a series of inflammatory responses caused by Mycoplasma species.

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