透析COVID-19幸存者的脑血流动力学改变:经颅多普勒超声对颅内压动力学的研究

Kidney and dialysis Pub Date : 2025-01-01 Epub Date: 2025-04-03 DOI:10.3390/kidneydial5020012
José Lapeña-Motilva, Daniel Fouz-Ruiz, Mariano Ruiz-Ortiz, Eduardo Sanpedro-Murillo, Sara Gómez-Enjuto, Inés Hernando-Jimenez, Aida Frias-González, Andrea Soledad Suso, Evangelina Merida-Herrero, Julián Benito-León
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引用次数: 0

摘要

背景:我们观察了一名患有脑室-腹膜分流术的COVID-19幸存者,他在血液透析期间出现颅内压升高。我们假设sars - cov -2感染后,患者可能会因颅内压变化而改变脑灌注压调节。方法:从2021年4月至7月,我们从马德里两个肾内科招募了既往感染COVID-19的透析患者。我们还招募了年龄和性别匹配的透析患者,此前没有SARS-CoV-2感染。采用经颅多普勒超声测量透析前和透析开始后30、60、90 min的大脑中动脉流速。结果:最终样本包括37例患者(16例感染covid -19, 21例未感染)。与未感染COVID-19的患者相比,COVID-19幸存者的脉搏指数在30至60分钟之间显着增加。他们的心率也更低。结论:我们提出两种机制:颅内压升高或动脉弹性降低。COVID-19幸存者的心率也较低。这项研究强调了SARS-CoV-2的多方面影响,包括潜在的长期血管和大脑影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebral Hemodynamic Alterations in Dialysis COVID-19 Survivors: A Transcranial Doppler Ultrasound Study on Intracranial Pressure Dynamics.

Background: We observed a COVID-19 survivor with a ventriculoperitoneal shunt who developed increased intracranial pressure during hemodialysis. We hypothesized that post-SARS-CoV-2 infection, patients may have altered cerebral perfusion pressure regulation in response to intracranial pressure changes.

Methods: From April to July 2021, we recruited dialysis patients with prior COVID-19 from two Madrid nephrology departments. We also recruited age- and sex-matched dialysis patients without prior SARS-CoV-2 infection. Transcranial Doppler ultrasound was used to measure the middle cerebral artery velocity before dialysis and 30, 60, and 90 min after the initiation of dialysis.

Results: The final sample included 37 patients (16 post-COVID-19 and 21 without). The COVID-19 survivors showed a significant pulsatility index increase between 30 and 60 min compared to those without COVID-19. They also had lower heart rates.

Conclusions: We propose two mechanisms: an increase in intracranial pressure or a decreased arterial elasticity. A lower heart rate was also observed in the COVID-19 survivors. This study highlights SARS-CoV-2's multifaceted effects, including potential long-term vascular and cerebral repercussions.

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