Tobias Laue, Maria Pilar Ballester, Lily Meoli, Carl Grabitz, Eva Uson, Lorenzo D Antiga, Valerie McLin, Montserrat Pujadas, Ângela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D'Amico, Raffaela Viganò, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Annelotte Broekhoven, Marjolein Kikkert, Shessy P Torres Morales, Sebenzile K Myeni, Mar Riveiro-Barciela, Adriana Palom, Nicola Zeni, Alessandra Brocca, Annarosa Cussigh, Sara Cmet, Maria Desamparados Escudero-García, Matteo Stocco, Leonardo Antonio Natola, Donatella Ieluzzi, Veronica Paon, Angelo Sangiovanni, Elisa Farina, Clara Dibenedetto, Yolanda Sánchez-Torrijos, Ana Lucena-Varela, Eva Román, Elisabet Sánchez, Rubén Sánchez-Aldehuelo, Julia López-Cardona, Dhaarica Jeyanesan, Alejandro Esquivel Morocho, Itzel Canas-Perez, Christine Eastgate, Simone Di Cola, Lucia Lapenna, Giacomo Zaccherini, Deborah Bongiovanni, Antonio Riva, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Paola Zanaga, Katia Sayaf, Sabir Hossain, Javier Crespo, Mercedes Robles-Díaz, Antonio Madejón, Helena Degroote, Marko Korenjak, Xavier Verhelst, Javier García-Samaniego, Raúl J Andrade, Paula Iruzubieta, Gavin Wright, Paolo Caraceni, Manuela Merli, Vishal C Patel, Amir Gander, Agustín Albillos, Germán Soriano, Maria Francesca Donato, David Sacerdoti, Pierluigi Toniutto, Maria Buti, Christophe Duvoux, Paolo Antonio Grossi, Thomas Berg, Wojciech G Polak, Massimo Puoti, Anna Bosch-Comas, Luca S Belli, Patrizia Burra, Francesco Paolo Russo, Minneke Coenraad, José Luis Calleja, Giovanni Perricone, Shilpa Chokshi, Marina Berenguer, Joan Clària, Richard Moreau, Javier Fernández, Vicente Arroyo, Paolo Angeli, Cristina Sánchez-Garrido, Javier Ampuero, Salvatore Piano, Emanuele Nicastro, Nathalie Rock, Debbie Shawcross, Lindsey Edwards, Frauke Mutschler, Anette Melk, Gautam Mehta, Ulrich Baumann, Rajiv Jalan
{"title":"儿童肝脏和肾脏移植受者对SARS-CoV-2疫苗的血清学反应比成人更强。","authors":"Tobias Laue, Maria Pilar Ballester, Lily Meoli, Carl Grabitz, Eva Uson, Lorenzo D Antiga, Valerie McLin, Montserrat Pujadas, Ângela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D'Amico, Raffaela Viganò, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Annelotte Broekhoven, Marjolein Kikkert, Shessy P Torres Morales, Sebenzile K Myeni, Mar Riveiro-Barciela, Adriana Palom, Nicola Zeni, Alessandra Brocca, Annarosa Cussigh, Sara Cmet, Maria Desamparados Escudero-García, Matteo Stocco, Leonardo Antonio Natola, Donatella Ieluzzi, Veronica Paon, Angelo Sangiovanni, Elisa Farina, Clara Dibenedetto, Yolanda Sánchez-Torrijos, Ana Lucena-Varela, Eva Román, Elisabet Sánchez, Rubén Sánchez-Aldehuelo, Julia López-Cardona, Dhaarica Jeyanesan, Alejandro Esquivel Morocho, Itzel Canas-Perez, Christine Eastgate, Simone Di Cola, Lucia Lapenna, Giacomo Zaccherini, Deborah Bongiovanni, Antonio Riva, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Paola Zanaga, Katia Sayaf, Sabir Hossain, Javier Crespo, Mercedes Robles-Díaz, Antonio Madejón, Helena Degroote, Marko Korenjak, Xavier Verhelst, Javier García-Samaniego, Raúl J Andrade, Paula Iruzubieta, Gavin Wright, Paolo Caraceni, Manuela Merli, Vishal C Patel, Amir Gander, Agustín Albillos, Germán Soriano, Maria Francesca Donato, David Sacerdoti, Pierluigi Toniutto, Maria Buti, Christophe Duvoux, Paolo Antonio Grossi, Thomas Berg, Wojciech G Polak, Massimo Puoti, Anna Bosch-Comas, Luca S Belli, Patrizia Burra, Francesco Paolo Russo, Minneke Coenraad, José Luis Calleja, Giovanni Perricone, Shilpa Chokshi, Marina Berenguer, Joan Clària, Richard Moreau, Javier Fernández, Vicente Arroyo, Paolo Angeli, Cristina Sánchez-Garrido, Javier Ampuero, Salvatore Piano, Emanuele Nicastro, Nathalie Rock, Debbie Shawcross, Lindsey Edwards, Frauke Mutschler, Anette Melk, Gautam Mehta, Ulrich Baumann, Rajiv Jalan","doi":"10.1097/TXD.0000000000001787","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR.</p><p><strong>Methods: </strong>A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA.</p><p><strong>Results: </strong>A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], <i>P</i> < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], <i>P</i> = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], <i>P</i> = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (<i>P</i> = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR.</p><p><strong>Conclusions: </strong>Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.</p>","PeriodicalId":23225,"journal":{"name":"Transplantation Direct","volume":"11 5","pages":"e1787"},"PeriodicalIF":1.9000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043343/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults.\",\"authors\":\"Tobias Laue, Maria Pilar Ballester, Lily Meoli, Carl Grabitz, Eva Uson, Lorenzo D Antiga, Valerie McLin, Montserrat Pujadas, Ângela Carvalho-Gomes, Ivan Sahuco, Ariadna Bono, Federico D'Amico, Raffaela Viganò, Elena Diago, Beatriz Tormo Lanseros, Elvira Inglese, Dani Martinez Vazquez, Annelotte Broekhoven, Marjolein Kikkert, Shessy P Torres Morales, Sebenzile K Myeni, Mar Riveiro-Barciela, Adriana Palom, Nicola Zeni, Alessandra Brocca, Annarosa Cussigh, Sara Cmet, Maria Desamparados Escudero-García, Matteo Stocco, Leonardo Antonio Natola, Donatella Ieluzzi, Veronica Paon, Angelo Sangiovanni, Elisa Farina, Clara Dibenedetto, Yolanda Sánchez-Torrijos, Ana Lucena-Varela, Eva Román, Elisabet Sánchez, Rubén Sánchez-Aldehuelo, Julia López-Cardona, Dhaarica Jeyanesan, Alejandro Esquivel Morocho, Itzel Canas-Perez, Christine Eastgate, Simone Di Cola, Lucia Lapenna, Giacomo Zaccherini, Deborah Bongiovanni, Antonio Riva, Rajni Sharma, Hio Lam Phoebe Tsou, Nicola Harris, Paola Zanaga, Katia Sayaf, Sabir Hossain, Javier Crespo, Mercedes Robles-Díaz, Antonio Madejón, Helena Degroote, Marko Korenjak, Xavier Verhelst, Javier García-Samaniego, Raúl J Andrade, Paula Iruzubieta, Gavin Wright, Paolo Caraceni, Manuela Merli, Vishal C Patel, Amir Gander, Agustín Albillos, Germán Soriano, Maria Francesca Donato, David Sacerdoti, Pierluigi Toniutto, Maria Buti, Christophe Duvoux, Paolo Antonio Grossi, Thomas Berg, Wojciech G Polak, Massimo Puoti, Anna Bosch-Comas, Luca S Belli, Patrizia Burra, Francesco Paolo Russo, Minneke Coenraad, José Luis Calleja, Giovanni Perricone, Shilpa Chokshi, Marina Berenguer, Joan Clària, Richard Moreau, Javier Fernández, Vicente Arroyo, Paolo Angeli, Cristina Sánchez-Garrido, Javier Ampuero, Salvatore Piano, Emanuele Nicastro, Nathalie Rock, Debbie Shawcross, Lindsey Edwards, Frauke Mutschler, Anette Melk, Gautam Mehta, Ulrich Baumann, Rajiv Jalan\",\"doi\":\"10.1097/TXD.0000000000001787\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR.</p><p><strong>Methods: </strong>A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA.</p><p><strong>Results: </strong>A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], <i>P</i> < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], <i>P</i> = 0.0032). 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引用次数: 0
摘要
背景：成人实体器官移植受者（SOTRs）对严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）疫苗接种的反应性降低，感染发生率较高，但儿童SOTRs的血清学反应资料很少。本研究的目的是确定儿童肝（LT）和肾移植（KT）受者对SARS-CoV-2疫苗接种的血清学反应，并将其与成人SOTR进行比较。方法：采用欧洲前瞻性多中心研究。接种COVID-19疫苗后第7周和32周采集样本，用ELISA测定血清学终点。结果：共纳入42例儿童（16例术后肝移植，26例术后kt）和117例成人（均为术后肝移植）。所有的儿童参与者和94%的成人参与者都接种了mRNA疫苗。在第7周，儿科SOTR患者的抗spike IgG水平显著高于成人（114 220.7 [59 285.92-220 058.55]vs . 8756.7 [5643.69-13 586.71], P P = 0.0032）。小儿LT和KT在第7周抗spike IgG应答方面无显著差异（129 434.4 [51 888.64-322 869.69]vs 105 304.5 [39 910.20-277 849.50], P = 0.9854）。在第7周和第32周，儿童和成人的抗刺突IgG下降率无差异（P = 0.8000）。男性和溶血性尿毒症综合征或缺血性肾病与儿童SOTR第7周抗spike IgG水平降低相关。结论：儿童SOTR表现出比可比成人SOTR患者更大的SARS-CoV-2疫苗应答。这些数据支持在儿童SOTR中接种SARS-CoV-2疫苗的有效性和安全性，并可能减轻该患者组的疫苗犹豫。
Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults.
Background: Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR.
Methods: A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA.
Results: A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR.
Conclusions: Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.
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