PPARG突变对家族性3型部分脂肪营养不良的综合影响：诊断和治疗策略。

IF 4.2 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

World Journal of Diabetes Pub Date : 2025-04-15 DOI:10.4239/wjd.v16.i4.103675

Heng-Li Lai, Liu Yang

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引用次数: 0

摘要

本文回顾了《世界糖尿病杂志》上的一篇论文。该研究揭示了PPARG基因突变与代谢紊乱（如胰岛素抵抗、糖尿病和高甘油三酯血症）之间的联系，并强调了基因检测在精确诊断和个性化治疗中的关键作用。本文进一步指出，深入研究PPARG突变的临床异质性及其潜在机制有助于优化治疗策略。同时，开发更有效的靶向治疗方法，开展广泛的基因组研究，对于了解家族性部分脂肪营养不良3型及相关代谢综合征具有重要意义。

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Comprehensive impact of PPARG mutations in familial partial lipodystrophy type 3: Diagnosis, therapeutic strategies.

This article reviews a paper in the World Journal of Diabetes. The study uncovers the link between PPARG gene mutations and metabolic disorders, such as insulin resistance, diabetes, and hypertriglyceridemia, and emphasizes the crucial role of genetic testing in precise diagnosis and personalized treatment. This article further points out that in-depth investigation into the clinical heterogeneity of PPARG mutations and their underlying mechanisms can contribute to optimizing management strategies. Meanwhile, the development of more effective targeted therapies and the conduct of extensive genomic research are of great significance for understanding familial partial lipodystrophy type 3 and related metabolic syndromes.

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来源期刊

World Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

自引率

2.40%

发文量

909

期刊介绍： The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.