持久性肠道细菌,表观遗传学和重度抑郁症。

IF 3.3 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Luis Vitetta, Matthew Bambling, Esben Strodl
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引用次数: 0

摘要

微生物-肠-脑轴已被认为是情绪障碍(如重度抑郁症)的潜在调节剂。该轴复杂的双向生化活动被认为参与不良情绪障碍。环境和遗传因素主导了最近关于抑郁症的讨论。抗生素处方、抗抑郁药、不良的负DNA甲基化反应和肠道微生物群失调被认为是抑郁症发生和发展的原因。虽然研究继续调查微生物组-肠-脑轴,但这篇综述将探讨肠道细菌的持续状态,这可能是由于不利的环境条件和/或药物处方导致的。肠道微生物群中的细菌休眠持续可能影响细菌表观基因组和DNA甲基化的作用。DNA甲基化是高度基序驱动的,对细菌表型有显著的控制,可以破坏肠道中的细菌代谢和神经递质形成,结果可能支持不利的情绪倾向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Persister Intestinal Bacteria, Epigenetics and Major Depression.

The microbiota-gut-brain axis has been proposed as a potential modulator of mood disorders such as major depression. Complex bidirectional biochemical activities in this axis have been posited to participate in adverse mood disorders. Environmental and genetic factors have dominated recent discussions on depression. The prescription of antibiotics, antidepressants, adverse negative DNA methylation reactions and a dysbiotic gut microbiome have been cited as causal for the development and progression of depression. While research continues to investigate the microbiome-gut-brain axis, this review will explore the state of persistence of gut bacteria that underpins bacterial dormancy, possibly due to adverse environmental conditions and/or pharmaceutical prescriptions. Bacterial dormancy persistence in the intestinal microbial cohort could affect the role of bacterial epigenomes and DNA methylations. DNA methylations are highly motif driven exerting significant control on bacterial phenotypes that can disrupt bacterial metabolism and neurotransmitter formation in the gut, outcomes that can support adverse mood dispositions.

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