自身免疫性疾病的细胞治疗策略

IF 6.2 Q1 IMMUNOLOGY

ImmunoTargets and Therapy Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.2147/ITT.S513629

Francisco B Quero, Tays Troncoso-Bravo, Mónica A Farías, Alexis M Kalergis

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引用次数: 0

摘要

目前，自身免疫性疾病的管理在安全性、有效性和特异性方面仍然是一个挑战。基于细胞的治疗策略已经成为自身免疫性疾病治疗的一种新方法，采用不同的细胞治疗平台，包括耐受性树突状细胞、调节性T细胞、常规和调节性嵌合抗原受体-T细胞、间充质干细胞和造血干细胞，每种细胞都有其生物学特征。在这里，我们讨论了不同的细胞治疗平台，它们的免疫作用机制，它们在自身免疫性疾病中的治疗潜力和益处，以及与它们的生产、规模、风险和患者安全相关的挑战。

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Cell-Based Therapeutic Strategies for Autoimmune Diseases.

Currently, the management of autoimmune disorders still being a challenge in terms of safety, efficiency, and specificity. Cell-based therapeutic strategies have emerged as a novel approach for autoimmune disease treatment, employing different cell therapy platforms, including tolerogenic dendritic cells, regulatory T cells, conventional and regulatory chimeric antigen receptor-T cells, mesenchymal and hematopoietic stem cells, each with their biological features. Here, we discuss the different cell therapy platforms, their immunological mechanisms of action, their therapeutic potential and benefits in autoimmune diseases, and challenges related to their production, scaling up, risks, and patient safety.

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来源期刊

ImmunoTargets and Therapy IMMUNOLOGY-

CiteScore

16.50

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.