莫斯科幽门螺杆菌耐药趋势分析

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Terapevticheskii Arkhiv Pub Date : 2025-03-26 DOI:10.26442/00403660.2025.02.203193

I V Maev, D N Andreev, A K Fomenko, M S Podporin, S V Lyamina, A V Zaborovsky, I N Khimina, S V Cheremushkin, A S Bagdasarian, N V Cheremushkina, E G Lobanova, V N Tsarev, O V Zayratyants

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引用次数: 0

摘要

目的：了解莫斯科地区患者幽门螺杆菌的初耐药趋势。材料和方法：作为临床和实验室研究的一部分，分析了2015年至2024年来自幽门螺旋杆菌感染患者的123份胃活检标本。通过快速脲酶试验和13c -脲酶呼吸试验证实幽门螺杆菌感染。采用厌氧培养技术。对纯培养物进行鉴定后，采用盘片扩散法测定其对阿莫西林- AMC、克拉霉素- CLR、甲硝唑- MET、四环素- TET四种抗菌药物的敏感性。结果：根据数据，整个样本池（n=123）对AMC的抵抗力为4.88%，CLR为16.26%，TET为3.25%，MET为46.34%。4.06%的菌株对CLR和MET双耐药。2015 - 2019年采集的28株菌株对AMC的耐药率为0.0%，CLR为10.71%，TET为0.0%，MET为50.0%。2020 - 2024年收集的菌株（n=95）耐药结构为：AMC - 6.32%, CLR - 17.89%, TET - 4.21%, MET - 45.26%。结论：莫斯科地区幽门螺杆菌对AMC、CLR、TET等抗菌药物的耐药性有逐渐增强的趋势，与其他研究数据一致。这种负面趋势可能最终导致俄罗斯目前使用的根除治疗方案的有效性下降。

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[Trends of antibiotic resistance of Helicobacter pylori in Moscow].

Aim: To determine the trends of primary antibiotic resistance of Helicobacter pylori strains isolated from patients living in Moscow.

Materials and methods: As part of a clinical and laboratory study, 123 gastric biopsy specimens from H. pylori-infected patients were analyzed from 2015 to 2024. H. pylori infection was verified by a rapid urease test and a ¹³C-urease breath test. The anaerobic culture technique was used. After identifying a pure culture, its susceptibility to four antibacterial agents (amoxicillin - AMC, clarithromycin - CLR, metronidazole - MET, tetracycline - TET) was determined by the disc diffusion method.

Results: According to the data, the resistance in the overall pool (n=123) of the test samples to AMC was 4.88%, CLR 16.26%, TET 3.25%, and MET 46.34%. Dual resistance to CLR and MET was detected in 4.06% of strains. Among strains collected from 2015 to 2019 (n=28), resistance to AMC was 0.0%, CLR 10.71%, TET 0.0%, and MET 50.0%. The structure of antibiotic resistance of strains collected from 2020 to 2024 (n=95) was as follows: AMC - 6.32%, CLR - 17.89%, TET - 4.21%, MET - 45.26%.

Conclusion: There is a gradual tendency to increase the resistance of H. pylori to antibacterial agents such as AMC, CLR, and TET in Moscow, which is consistent with the data of other studies. This negative trend may eventually lead to decreased effectiveness of currently used eradication therapy regimens in Russia.

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来源期刊

Terapevticheskii Arkhiv 医学-医学：内科

CiteScore

1.40

自引率

33.30%

发文量

171

审稿时长

3-8 weeks

期刊介绍： Терапевтический архив The journal was founded by the prominent Russian therapists M.P. Konchalovsky and G.F. Lang in 1923. Then its editors-in-chief were Professors V.N. Vinogradov and A.G. Gukasyan. Since 1972, E.I. Chazov, Academician of the Russian Academy of Sciences, has been heading the editorial board of the journal. Over 90 years, there have been more than 1000 issues where the authors and editorial staff have done their best for readers to keep abreast of current advances in medical science and practice and for physicians to master the advanced principles of recognition and treatment of a wide spectrum of visceral diseases. The papers published in the journal (editorials, original articles, lectures, reviews, etc.) cover both current scientific achievements and practical experience in diagnosing, treating, and preventing visceral diseases. The authors of publications are not only Russian, but also foreign scientists and physicians. All papers are peer-reviewed by highly qualified Russian specialists. The journal is published monthly. Traditionally, each issue has predominantly certain thematic areas covering individual therapy specializations. Every year, one of the issues is devoted to related problems in practical medicine (allergology and immunology, neurology and psychiatry, obstetrics, oncology, etc.). This all draws the attention of the reading public to the journal. The journal is indexed in RSCI (Russian Science Citation Index), PubMed/Medline, Index Medicus, Scopus/EMBASE, Web of Science Core Collection (Science Citation Index Expanded), Web of Science (Russian Science Citation Index - RSCI, Current Contents Connect, BIOSIS Previews), Google Scholar, Ulrich''s Periodicals Directory. The journal is included in the list of periodicals recommended by the Higher Attestation Committee for publishing the papers containing the basic materials of doctoral and candidate dissertations. By the decision of the Presidium of the Russian Academy of Medical Sciences, the “Therapevticheskiy Arkhiv” was awarded the Botkin medal. It was admitted to the European Association of Sciences Editors (EASE). The journal was honored with the Golden Press Fund decoration at the 13th International Press Professional Exhibition.