中国农村老年人脑血管病:患病率、分布及相关因素

IF 4.1 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2025-04-04 eCollection Date: 2025-01-01 DOI:10.1093/braincomms/fcaf136
Huisi Zhang, Chunyan Li, Jiafeng Wang, Mingqing Zhao, Ziwei Chen, Qianqian Xie, Tao Gong, Tingting Hou, Yongxiang Wang, Lin Cong, Lenore J Launer, Lin Song, Yifeng Du, Chengxuan Qiu
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引用次数: 0

摘要

脑血管病(cSVD)在普通人群,特别是农村老年人中的流行病学特征尚不明确。在这里,我们报告了中国农村老年人口中心血管疾病的患病率、分布和相关因素。这项基于人群的横断面研究纳入了1272名老年人(年龄≥60岁;平均年龄69.43岁;(58.57%的女性),在2018-2020年接受了脑部结构MRI扫描(3.0T)。按照神经影像学血管改变报告标准-1标准评估cSVD的MRI标志物。我们进行了描述性和回归分析。脑微出血(CMBs)的总患病率为20.31%,脑腔隙为26.87%,基底节区血管周围间隙(PVS)为60.06%,半瓣膜区PVS为76.31%,深白质高信号(wmh)为95.74%,脑室周围wmh为94.17%。随着年龄的增长,所有cSVD标志物的患病率都增加了,除了半子叶中心的PVS。女性中重度深部腰痛发生率高于男性(P = 0.005)。老年和高血压与所有心血管疾病标志物的可能性增加有关。较高的身体质量指数与更多的wmh有关。冠心病(CHD)与WMHs、CMBs和腔隙相关。我们的研究表明,cSVD,尤其是wmh和PVS,在中国农村老年人中非常普遍。老年、高血压和冠心病与明显的心血管疾病相关。未来有必要进行前瞻性队列研究,以确定心血管疾病的发病率和主要危险因素,从而促进预防干预,减轻资源有限地区心血管疾病的负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebral small vessel disease among rural-dwelling Chinese older adults: prevalence, distribution, and associated factors.

Epidemiological characteristics of cerebral small vessel disease (cSVD) in the general population, especially among rural older adults, are poorly defined. Here, we reported the prevalence, distribution, and associated factors of cSVD in a rural-dwelling older population in China. This population-based cross-sectional study included 1272 older adults (age ≥60 years; mean age 69.43 years; 58.57% women) who underwent structural brain MRI scans (3.0T) in 2018-2020. MRI markers of cSVD were assessed following the Standards for Reporting Vascular Changes on Neuroimaging-1 criteria. We performed descriptive and regression analyses. The overall prevalence was 20.31% for cerebral microbleeds (CMBs), 26.87% for lacunes, 60.06% for basal ganglia perivascular spaces (PVS), 76.31% for centrum semiovale PVS, 95.74% for deep white matter hyperintensities (WMHs), and 94.17% for periventricular WMHs. The prevalence increased with advancing age for all cSVD markers, except PVS in the centrum semiovale. The prevalence of moderate-to-severe deep WMHs was higher in women than in men (P = 0.005). Older age and hypertension were associated with increased likelihoods of all cSVD markers. A higher body mass index was linked to more WMHs. Coronary heart disease (CHD) was associated with WMHs, CMBs, and lacunes. Our study suggests that cSVD, especially WMHs and PVS, was highly prevalent among rural Chinese older adults. Older age, hypertension, and CHD are associated with distinct cSVD. Future prospective cohort studies are warranted to determine incidence and major risk factors of cSVD, which could facilitate preventive interventions to reduce the burden of cSVD in resource-limited settings.

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