Fatma Ozer, Fatih Baygutalp, Muhammet Celik, Nurcan Kılıc Baygutalp
{"title":"痛风患者脂肪因子、氧化应激和炎症标志物的评价。","authors":"Fatma Ozer, Fatih Baygutalp, Muhammet Celik, Nurcan Kılıc Baygutalp","doi":"10.46497/ArchRheumatol.2025.11001","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the role of adipokines, oxidative stress, and inflammatory markers in the pathogenesis of gout.</p><p><strong>Patients and methods: </strong>Between September 2021 and December 2022, a total of 88 volunteers including 44 patients (37 males, 7 females; mean age: 56.5±11.6 years; range, 30 to 77 years) with gout disease and 44 age- and sex-matched healthy controls (37 males, 7 females; mean age: 54.3±12.1 years; range, 30 to 78 years) were retrospectively analyzed. Serum interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), irisin, resistin, total oxidant status (TOS), and total antioxidant status (TAS) levels were analyzed.</p><p><strong>Results: </strong>The mean serum irisin levels were significantly higher in patients with gout than in the healthy controls (405.6±97.3 and 316.0±80.8 pg/mL, respectively). The mean IL-10 levels were significantly lower in patients with gout than in healthy controls (90.8±71.9 and 172.7±128.6 pg/mL, respectively). There was no statistically significant difference in the serum resistin, TNF-α, TOS, or TAS levels between the groups (p>0.05).</p><p><strong>Conclusion: </strong>Our study results show that serum irisin and IL-10 seem to be candidate biomarkers of diagnosis of gout.</p>","PeriodicalId":93884,"journal":{"name":"Archives of rheumatology","volume":"40 1","pages":"112-122"},"PeriodicalIF":1.1000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010260/pdf/","citationCount":"0","resultStr":"{\"title\":\"Evaluation of adipokines, oxidative stress, and inflammatory markers in gout patients.\",\"authors\":\"Fatma Ozer, Fatih Baygutalp, Muhammet Celik, Nurcan Kılıc Baygutalp\",\"doi\":\"10.46497/ArchRheumatol.2025.11001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This study aims to investigate the role of adipokines, oxidative stress, and inflammatory markers in the pathogenesis of gout.</p><p><strong>Patients and methods: </strong>Between September 2021 and December 2022, a total of 88 volunteers including 44 patients (37 males, 7 females; mean age: 56.5±11.6 years; range, 30 to 77 years) with gout disease and 44 age- and sex-matched healthy controls (37 males, 7 females; mean age: 54.3±12.1 years; range, 30 to 78 years) were retrospectively analyzed. Serum interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), irisin, resistin, total oxidant status (TOS), and total antioxidant status (TAS) levels were analyzed.</p><p><strong>Results: </strong>The mean serum irisin levels were significantly higher in patients with gout than in the healthy controls (405.6±97.3 and 316.0±80.8 pg/mL, respectively). The mean IL-10 levels were significantly lower in patients with gout than in healthy controls (90.8±71.9 and 172.7±128.6 pg/mL, respectively). There was no statistically significant difference in the serum resistin, TNF-α, TOS, or TAS levels between the groups (p>0.05).</p><p><strong>Conclusion: </strong>Our study results show that serum irisin and IL-10 seem to be candidate biomarkers of diagnosis of gout.</p>\",\"PeriodicalId\":93884,\"journal\":{\"name\":\"Archives of rheumatology\",\"volume\":\"40 1\",\"pages\":\"112-122\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010260/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of rheumatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46497/ArchRheumatol.2025.11001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of rheumatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46497/ArchRheumatol.2025.11001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Evaluation of adipokines, oxidative stress, and inflammatory markers in gout patients.
Objectives: This study aims to investigate the role of adipokines, oxidative stress, and inflammatory markers in the pathogenesis of gout.
Patients and methods: Between September 2021 and December 2022, a total of 88 volunteers including 44 patients (37 males, 7 females; mean age: 56.5±11.6 years; range, 30 to 77 years) with gout disease and 44 age- and sex-matched healthy controls (37 males, 7 females; mean age: 54.3±12.1 years; range, 30 to 78 years) were retrospectively analyzed. Serum interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), irisin, resistin, total oxidant status (TOS), and total antioxidant status (TAS) levels were analyzed.
Results: The mean serum irisin levels were significantly higher in patients with gout than in the healthy controls (405.6±97.3 and 316.0±80.8 pg/mL, respectively). The mean IL-10 levels were significantly lower in patients with gout than in healthy controls (90.8±71.9 and 172.7±128.6 pg/mL, respectively). There was no statistically significant difference in the serum resistin, TNF-α, TOS, or TAS levels between the groups (p>0.05).
Conclusion: Our study results show that serum irisin and IL-10 seem to be candidate biomarkers of diagnosis of gout.
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