中性粒细胞与淋巴细胞比率和单核细胞与淋巴细胞比率作为评估阿西尔地区糖尿病患者血糖状态的炎症标志物。

Q1 Health Professions
Ayed A Dera, Abeer Abdullah Alghamdi, Mesfer Al-Shahrani, Reem M Al-Gahtani, Bashayer Saad Alghamdi, Gaffar Sarwar Zaman, Mohammed Abdul Rasheed, Hassan Al-Shehri, Lana Al-Qhtani, Syed Parween Ali, Umme Hani, Talha Bin Emran
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引用次数: 0

摘要

背景:糖尿病(DM)是一种以高血糖水平为特征的普遍慢性代谢疾病,由胰岛素分泌不足或胰岛素使用无效引起,是严重的全球健康问题。关于血糖状态与中性粒细胞与淋巴细胞之比(NLR)和单核细胞与淋巴细胞之比(MLR)之间关系的研究有限。本研究旨在通过检查糖尿病和Asir区域炎症标志物之间的联系来填补这些知识空白。方法:对3545名参与者的资料进行回顾性分析。该数据集收集于2021年至2023年之间,包括从未来实验室先锋数据库获得的38项实验室测试。该研究的纳入标准侧重于糖尿病特征测试(糖化血红蛋白[HbA1c]和空腹血糖[FBG])和人工计算的炎症标志物(NLR和MLR),这些指标按年龄和性别分层。结果:该研究表明,与FBG水平相比,NLR水平在所有成年年龄组和成年女性参与者中存在显著差异(p结论:尽管本研究需要更大的样本量,但结果表明,NLR和MLR可以作为评估糖代谢紊乱人群炎症的有价值指标,特别是在成人和女性人群中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios as inflammatory markers in the assessment of glycemic status in diabetic patients of Asir region.

Background: Diabetes mellitus (DM) is a prevalent chronic metabolic condition characterized by high blood sugar levels, resulting from insufficient insulin production or ineffective insulin use, posing substantial global health issues. Research on the relationship between glycemic status and the ratio of neutrophils to lymphocytes (NLR) and monocytes to lymphocytes (MLR) is limited. This study aimed to fill these knowledge gaps by examining the connection between DM and inflammatory markers within the Asir region.

Methods: Data from 3545 participants were retrospectively analyzed. The dataset, gathered between 2021 and 2023, comprises 38 laboratory tests obtained from the Future Lab Pioneer database. The study's inclusion criteria focused on diabetes profile tests (glycated hemoglobin [HbA1c] and fasting blood glucose [FBG]) and manually computed inflammatory markers (NLR and MLR), which were stratified by age and sex.

Results: This study demonstrated significant differences in NLR levels compared with FBG levels across all adult age groups and adult female participants (p < 0.0001), as well as among all elderly age groups (p = 0.0006) and elderly women (p = 0.01). MLR levels were significant in all adult age groups (p = 0.04) and in adult women (p = 0.02). When NLR and MLR were compared to HbA1c levels, a significant difference in the mean NLR was found in adult women (p = 0.005). Additionally, the mean MLR levels were significant in all adult age groups (p = 0.04) and adult women (p = 0.02).

Conclusion: Although a larger sample size is necessary for this research, the results indicate that NLR and MLR could serve as valuable indicators for evaluating inflammation in people with disrupted glucose metabolism, particularly in adult and female populations.

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