{"title":"血红蛋白糖化指数和甘油三酯-葡萄糖指数与糖尿病肾病有关。","authors":"Emel Tatli","doi":"10.24875/CIRU.23000213","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Diabetic nephropathy (DN) is a significant complication of diabetes. Despite strict management of fasting plasma glucose (FPG), DN may progress to end-stage renal disease. HbA1c, the best biomarker for glycemic management, may differ in similar FPG. Hemoglobin glycation index (HGI) = HbA1c as determined minus HbA1c as predicted. The triglyceride-glucose index (TGI) is found to detect insulin resistance and correlates with DN. The aim of this study is to see the association of TGI and HGI with diabetic nephropathy in type 2 diabetes patients.</p><p><strong>Method: </strong>234 patients with type 2 diabetes were analyzed retrospectively.</p><p><strong>Results: </strong>87 (37.2%) of 234 patients were male, and the mean age was 57.2 ± 11.1 years. 76 of the patients had DN. HGI and TGI were significantly higher in the DN group (2.59 ± 1.7 vs. 1.18 ± 0.34; p = 0.00 and 9.9 ± 0.7 vs. 9.7 ± 0.7; p = 0.024). In logistic regression analysis, microalbuminuria was associated with TGI (OR = 3.35, 95% CI, 1.778- 6.32, p = 0.01) and HGI (OR = 2.579, 95% CI, 1.89-3.516, p = 0.00).</p><p><strong>Conclusions: </strong>In conclusion, TGI and HGI were independently associated with diabetic nephropathy. These markers may be useful in DN, especially in anemic individuals, since anemia might affect HbA1c levels.</p>","PeriodicalId":93936,"journal":{"name":"Cirugia y cirujanos","volume":"93 1","pages":"41-46"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hemoglobin glycation index and triglyceride-glucose index are related to diabetic nephropathy.\",\"authors\":\"Emel Tatli\",\"doi\":\"10.24875/CIRU.23000213\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Diabetic nephropathy (DN) is a significant complication of diabetes. Despite strict management of fasting plasma glucose (FPG), DN may progress to end-stage renal disease. HbA1c, the best biomarker for glycemic management, may differ in similar FPG. Hemoglobin glycation index (HGI) = HbA1c as determined minus HbA1c as predicted. The triglyceride-glucose index (TGI) is found to detect insulin resistance and correlates with DN. The aim of this study is to see the association of TGI and HGI with diabetic nephropathy in type 2 diabetes patients.</p><p><strong>Method: </strong>234 patients with type 2 diabetes were analyzed retrospectively.</p><p><strong>Results: </strong>87 (37.2%) of 234 patients were male, and the mean age was 57.2 ± 11.1 years. 76 of the patients had DN. HGI and TGI were significantly higher in the DN group (2.59 ± 1.7 vs. 1.18 ± 0.34; p = 0.00 and 9.9 ± 0.7 vs. 9.7 ± 0.7; p = 0.024). In logistic regression analysis, microalbuminuria was associated with TGI (OR = 3.35, 95% CI, 1.778- 6.32, p = 0.01) and HGI (OR = 2.579, 95% CI, 1.89-3.516, p = 0.00).</p><p><strong>Conclusions: </strong>In conclusion, TGI and HGI were independently associated with diabetic nephropathy. These markers may be useful in DN, especially in anemic individuals, since anemia might affect HbA1c levels.</p>\",\"PeriodicalId\":93936,\"journal\":{\"name\":\"Cirugia y cirujanos\",\"volume\":\"93 1\",\"pages\":\"41-46\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cirugia y cirujanos\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24875/CIRU.23000213\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cirugia y cirujanos","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24875/CIRU.23000213","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的：糖尿病肾病（DN）是糖尿病的重要并发症。尽管严格控制空腹血糖（FPG）， DN仍可能发展为终末期肾脏疾病。糖化血红蛋白是血糖管理的最佳生物标志物，在类似的FPG中可能有所不同。血红蛋白糖化指数(HGI) =测定的HbA1c减去预测的HbA1c。甘油三酯-葡萄糖指数（TGI）被发现检测胰岛素抵抗并与DN相关。本研究的目的是观察TGI和HGI与2型糖尿病患者糖尿病肾病的关系。方法：对234例2型糖尿病患者进行回顾性分析。结果：234例患者中男性87例（37.2%），平均年龄57.2±11.1岁。76例患者患有DN。DN组HGI和TGI显著高于DN组(2.59±1.7 vs. 1.18±0.34；P = 0.00和9.9±0.7 vs. 9.7±0.7；P = 0.024)。在logistic回归分析中，微量白蛋白尿与TGI （OR = 3.35, 95% CI, 1.778 ~ 6.32, p = 0.01）和HGI （OR = 2.579, 95% CI, 1.89 ~ 3.516, p = 0.00）相关。结论：TGI和HGI与糖尿病肾病独立相关。这些标记物可能对DN有用，特别是对贫血个体，因为贫血可能影响HbA1c水平。
Hemoglobin glycation index and triglyceride-glucose index are related to diabetic nephropathy.
Objective: Diabetic nephropathy (DN) is a significant complication of diabetes. Despite strict management of fasting plasma glucose (FPG), DN may progress to end-stage renal disease. HbA1c, the best biomarker for glycemic management, may differ in similar FPG. Hemoglobin glycation index (HGI) = HbA1c as determined minus HbA1c as predicted. The triglyceride-glucose index (TGI) is found to detect insulin resistance and correlates with DN. The aim of this study is to see the association of TGI and HGI with diabetic nephropathy in type 2 diabetes patients.
Method: 234 patients with type 2 diabetes were analyzed retrospectively.
Results: 87 (37.2%) of 234 patients were male, and the mean age was 57.2 ± 11.1 years. 76 of the patients had DN. HGI and TGI were significantly higher in the DN group (2.59 ± 1.7 vs. 1.18 ± 0.34; p = 0.00 and 9.9 ± 0.7 vs. 9.7 ± 0.7; p = 0.024). In logistic regression analysis, microalbuminuria was associated with TGI (OR = 3.35, 95% CI, 1.778- 6.32, p = 0.01) and HGI (OR = 2.579, 95% CI, 1.89-3.516, p = 0.00).
Conclusions: In conclusion, TGI and HGI were independently associated with diabetic nephropathy. These markers may be useful in DN, especially in anemic individuals, since anemia might affect HbA1c levels.
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