[abo -错配造血干细胞移植后治疗纯红细胞发育不全期间的拉里弯曲杆菌菌血症]。

Ryo Yoshimaru, Hirotaka Nakamura, Yony-Mei Guo, Song-Gi Chi, Yousuke Minami, Yusuke Ainoda, Keiji Okinaka, Junichiro Yuda
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引用次数: 0

摘要

lari弯曲杆菌是一种罕见的引起菌血症的弯曲杆菌,临床过程和症状因报告而异,没有标准的抗菌药物选择和治疗时间。一名68岁的男性接受了单倍同型造血干细胞移植(HSCT),来自一名abo血型不相容的主要供体,移植后使用环磷酰胺治疗骨髓增生异常综合征,结果出现了纯粹的红细胞贫血和输血后铁超载。第360天,患者出现发热,血培养检出革兰氏阴性螺旋菌。质谱鉴定该分离物为lari。该分离株对左氧氟沙星耐药,给予静脉注射头孢吡肟后口服阿莫西林维持治疗。我们在此报告首例异体造血干细胞移植后发生的拉里梭菌血症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Campylobacter lari bacteremia during treatment of pure red cell aplasia following major ABO-mismatched hematopoietic stem cell transplantation].

Campylobacter lari is a rare cause of bacteremia in Campylobacter spp. Clinical course and symptoms vary by report, and no standard approaches to antimicrobial selection and duration of treatment have been established. A 68-year-old man who underwent haploidentical hematopoietic stem cell transplantation (HSCT) from a major ABO-incompatible donor with post-transplant cyclophosphamide for myelodysplastic syndromes developed pure red cell anemia and post-transfusion iron overload. On day 360, the patient developed fever and spiral-shaped gram-negative bacteria were detected by blood culture. The isolate was identified as C. lari by mass spectrometry. The isolate was resistant to levofloxacin, and intravenous cefepime was given followed by maintenance therapy with oral amoxicillin. We here report the first case of C. lari bacteremia developing after allogeneic HSCT.

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