银屑病关节炎的免疫反应和细胞因子通路:系统综述。

IF 1.1 Q4 RHEUMATOLOGY
Archives of rheumatology Pub Date : 2025-03-17 eCollection Date: 2025-03-01 DOI:10.46497/ArchRheumatol.2025.10934
Gamze Dilek, Mehtap Kalcik Unan, Kemal Nas
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引用次数: 0

摘要

目的:本文综述了先天免疫和适应性免疫细胞及其分子信号通路在银屑病关节炎(PsA)临床表型病理生理中的作用。材料与方法:以“银屑病”、“银屑病关节炎”、“发病机制”、“适应性免疫系统”、“病理生理学”、“骨与软骨损伤”、“细胞因子通路”为关键词,在PubMed数据库中进行系统的文献检索。结果:临床研究和体外研究的适应性和先天免疫系统细胞和介导活化这些细胞在PsA发病机制。详细解释了影响PsA发病机制的细胞因子通路在该疾病最常见的临床表型中的作用。结论:本文综述了银屑病关节炎免疫机制中可能涉及的细胞因子通路。我们相信这篇综述将有助于更好地理解疾病临床表型的发病机制和疾病管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immune response and cytokine pathways in psoriatic arthritis: A systematic review.

Objectives: This review aims to focus on the role of innate and adaptive immune system cells and their molecular signaling pathways in the pathophysiology of clinical phenotypes of psoriatic arthritis (PsA).

Materials and methods: A systematic literature search was conducted in the PubMed database using the key words "psoriasis," "psoriatic arthritis," "pathogenesis," "adaptive immune system," "pathophysiology," "bone and cartilage damage," and "cytokine pathways."

Results: Clinical studies and in vitro studies on adaptive and innate immune system cells and mediators that cause activation of these cells in the pathogenesis of PsA were examined. The role of cytokine pathways affecting the pathogenesis of PsA on the most common clinical phenotypes of the disease were explained in detail.

Conclusion: In this article, we reviewed the cytokine pathways that may contribute to the immunological pathogenesis of psoriatic arthritis. We believe that this review will contribute to a better understanding of the pathogenesis of the clinical phenotypes of the disease and to disease management.

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