Cefepime-induced神经毒性。

IF 1.4 Q4 INFECTIOUS DISEASES

Southern African Journal of Infectious Diseases Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI:10.4102/sajid.v40i1.704

Jessica Taylor, Hannah M Gunter, Karen Cohen

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引用次数: 0

摘要

我们提出了一例严重的头孢吡肟诱导神经毒性急性肾损伤后患者与骨折相关的感染。尽管停用了头孢吡肟，患者仍需要插管、通气、多种抗癫痫药物来控制癫痫发作和血液透析。贡献：头孢吡肟引起的神经毒性是脑病的可逆原因。早期识别和停用头孢吡肟至关重要。由于抗微生物药物耐药性，南非的头孢吡肟使用量增加，卫生保健工作者必须意识到这种未被充分认识和报告的严重药物不良反应。

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Cefepime-induced neurotoxicity.

We present a case of severe cefepime-induced neurotoxicity following acute kidney injury in a patient with a fracture-related infection. Despite stopping cefepime, the patient required intubation, ventilation, multiple antiepileptic drugs for seizure control, and haemodialysis.

Contribution: Cefepime-induced neurotoxicity is a reversible cause of encephalopathy. Early recognition and cefepime withdrawal are crucial. As cefepime use in South Africa increases due to antimicrobial resistance, healthcare workers must be aware of this under-recognised, under-reported serious adverse drug reaction.

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来源期刊

Southern African Journal of Infectious Diseases INFECTIOUS DISEASES-

自引率

11.10%

发文量

审稿时长

52 weeks