与原发性胆汁性肝硬化相关的反复低血糖昏迷发作。

JCEM case reports Pub Date : 2025-04-10 eCollection Date: 2025-05-01 DOI:10.1210/jcemcr/luaf030
Yang Liu, Jianbin Xu, Yimei Chen, Lingling Wang, Wen Chen, Jing Shen
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摘要

原发性胆道胆管炎(PBC)是一种以小叶间胆管炎症为特征的慢性胆汁淤积性肝病,可导致纤维化和肝硬化。很少有研究探讨低血糖与PBC的关系。在这个病例中,一名76岁的中国男性被诊断为PBC,出现了反复的昏迷发作。患者有严重低血糖,肝功能检查有轻微异常。此外,患者抗线粒体抗体、抗线粒体抗体亚型2、着丝粒蛋白B抗体、抗可溶性酸性核蛋白100抗体均呈阳性,诊断为PBC。患者还经历过空腹低血糖昏迷,需要彻底评估以确定潜在原因。本病例提示,在这种情况下,肝源性低血糖与PBC相关可能比自身免疫相关的低血糖更常见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recurrent Hypoglycemic Coma Episodes Associated With Primary Biliary Cirrhosis.

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by interlobular bile duct inflammation, which causes fibrosis and cirrhosis. Few studies have explored the association of hypoglycemia with PBC. In this case, a 76-year-old Chinese man diagnosed with PBC developed recurrent comatose episodes. The patient had severe hypoglycemia and slight abnormalities in liver function tests. In addition, the patient had positive results in antimitochondrial antibody, anti-mitochondrial antibody-subtype 2, centromeric protein B antibody, and antisoluble acidic nuclear protein 100 antibody levels, which led to the diagnosis of PBC. The patient also experienced fasting hypoglycemic coma, requiring thorough evaluation to identify potential causes. This case suggests that liver-derived hypoglycemia associated with PBC may be more common than autoimmune-related hypoglycemia in this context.

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