COVID-19感染介导的急性黄斑神经视网膜病变临床特征及发病机制探讨

IF 3.3 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yixuan Xi, Ziyi Zhou, Tianfang Chang, Guorui Dou, Zhaojie Chu
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引用次数: 0

摘要

急性黄斑神经视网膜病变(AMN)是一种罕见的视网膜疾病,主要影响年轻女性。在COVID-19大流行期间,AMN的发病率显着增加,从而为阐明该疾病的病因提供了独特的机会。在本研究中,我们回顾了24篇文章报道的59例患者。患者平均年龄33.51±14.02岁,年龄16 ~ 75岁,女性占71.19%。感染后眼部症状的平均持续时间为8.22±10.69 d,范围为4 ~ 150 d。本研究探讨了AMN的潜在发病机制,包括COVID-19对视网膜神经血管结构和功能的影响、免疫介导的炎症因子产生、血视网膜屏障破坏和视网膜微血管损伤,以及潜在的临床治疗干预措施。本研究为AMN的进一步研究提供了理论框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute Macular Neuroretinopathy Mediated by COVID-19 Infection: Insights into its Clinical Features and Pathogenesis.

Acute macular neuroretinopathy (AMN) is a rare retinal condition that predominantly affects young females. The incidence of AMN increased significantly during the COVID-19 pandemic, thereby providing a unique opportunity to elucidate the etiology of this disease. In the present study, 24 articles reporting 59 patients were reviewed. The average age of the patients was 33.51 ± 14.02 years, ranging from 16 to 75 years, with females comprising 71.19% of the cases. The average duration of ocular symptoms post-infection was 8.22 ± 10.69 days, ranging from 4 to 150 days. This study investigated the potential pathogenesis of AMN, including the impact of COVID-19 on retinal neurovascular structure and function, immune-mediated inflammatory factor production, blood-retinal barrier disruption, and retinal microvascular damage, as well as potential clinical therapeutic interventions. This research provides a theoretical framework that can inform further investigations of AMN.

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