Marianne Lannsjö, Jörgen Borg, Anders Lewén, Charlotta VON Seth, Per Enblad, Sami Abu Hamdeh
{"title":"中度至重度弥漫性轴索创伤性脑损伤的长期预后：一项前瞻性研究。","authors":"Marianne Lannsjö, Jörgen Borg, Anders Lewén, Charlotta VON Seth, Per Enblad, Sami Abu Hamdeh","doi":"10.2340/jrm-cc.v8.42299","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Traumatic brain injury (TBI) with diffuse axonal injury (DAI) necessitates significant medical and rehabilitation interventions. The late long-term outcome is variable with potential for neurodegenerative development and deterioration. This study evaluates the late long-term outcomes of moderate to severe TBI with DAI.</p><p><strong>Methods: </strong>Patients aged 16-65 with moderate to severe TBI and DAI were included. From 2006 to 2018, 30 patients (mean age 34; 21 males, 9 females) were enrolled. Outcomes were assessed using the Glasgow Outcome Scale Extended (GOSE) at 6 months and ≥ 1-year post-injury.</p><p><strong>Results: </strong>At 6 months, 10 patients had a favourable outcome (GOSE 6-8), increasing to 12 at ≥ 1-year post-injury. Patients with unfavourable outcomes were older (mean 40) than those with favourable outcomes (mean 24, <i>p</i> < 0.001). DAI stage correlated with outcomes (<i>p</i> = 0.003). GOSE remained unchanged in 15 patients, improved in 9 and deteriorated in 6 between the 6 months and the ≥ 1-year follow-up.</p><p><strong>Discussion: </strong>Approximately one-third of TBI patients with DAI achieved favourable long-term outcomes, and the outcome changed in half of the patients between 6 months and ≥ 1 year follow-up. Age and DAI stage were significant predictors of outcome. Further studies are required to enhance prognostic accuracy and explore rehabilitation's impact.</p>","PeriodicalId":73929,"journal":{"name":"Journal of rehabilitation medicine. Clinical communications","volume":"8 ","pages":"42299"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986268/pdf/","citationCount":"0","resultStr":"{\"title\":\"LONG-TERM OUTCOMES OF MODERATE TO SEVERE DIFFUSE AXONAL TRAUMATIC BRAIN INJURY: A PROSPECTIVE STUDY.\",\"authors\":\"Marianne Lannsjö, Jörgen Borg, Anders Lewén, Charlotta VON Seth, Per Enblad, Sami Abu Hamdeh\",\"doi\":\"10.2340/jrm-cc.v8.42299\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Traumatic brain injury (TBI) with diffuse axonal injury (DAI) necessitates significant medical and rehabilitation interventions. The late long-term outcome is variable with potential for neurodegenerative development and deterioration. This study evaluates the late long-term outcomes of moderate to severe TBI with DAI.</p><p><strong>Methods: </strong>Patients aged 16-65 with moderate to severe TBI and DAI were included. From 2006 to 2018, 30 patients (mean age 34; 21 males, 9 females) were enrolled. Outcomes were assessed using the Glasgow Outcome Scale Extended (GOSE) at 6 months and ≥ 1-year post-injury.</p><p><strong>Results: </strong>At 6 months, 10 patients had a favourable outcome (GOSE 6-8), increasing to 12 at ≥ 1-year post-injury. Patients with unfavourable outcomes were older (mean 40) than those with favourable outcomes (mean 24, <i>p</i> < 0.001). DAI stage correlated with outcomes (<i>p</i> = 0.003). GOSE remained unchanged in 15 patients, improved in 9 and deteriorated in 6 between the 6 months and the ≥ 1-year follow-up.</p><p><strong>Discussion: </strong>Approximately one-third of TBI patients with DAI achieved favourable long-term outcomes, and the outcome changed in half of the patients between 6 months and ≥ 1 year follow-up. Age and DAI stage were significant predictors of outcome. Further studies are required to enhance prognostic accuracy and explore rehabilitation's impact.</p>\",\"PeriodicalId\":73929,\"journal\":{\"name\":\"Journal of rehabilitation medicine. 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Clinical communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2340/jrm-cc.v8.42299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
LONG-TERM OUTCOMES OF MODERATE TO SEVERE DIFFUSE AXONAL TRAUMATIC BRAIN INJURY: A PROSPECTIVE STUDY.
Introduction: Traumatic brain injury (TBI) with diffuse axonal injury (DAI) necessitates significant medical and rehabilitation interventions. The late long-term outcome is variable with potential for neurodegenerative development and deterioration. This study evaluates the late long-term outcomes of moderate to severe TBI with DAI.
Methods: Patients aged 16-65 with moderate to severe TBI and DAI were included. From 2006 to 2018, 30 patients (mean age 34; 21 males, 9 females) were enrolled. Outcomes were assessed using the Glasgow Outcome Scale Extended (GOSE) at 6 months and ≥ 1-year post-injury.
Results: At 6 months, 10 patients had a favourable outcome (GOSE 6-8), increasing to 12 at ≥ 1-year post-injury. Patients with unfavourable outcomes were older (mean 40) than those with favourable outcomes (mean 24, p < 0.001). DAI stage correlated with outcomes (p = 0.003). GOSE remained unchanged in 15 patients, improved in 9 and deteriorated in 6 between the 6 months and the ≥ 1-year follow-up.
Discussion: Approximately one-third of TBI patients with DAI achieved favourable long-term outcomes, and the outcome changed in half of the patients between 6 months and ≥ 1 year follow-up. Age and DAI stage were significant predictors of outcome. Further studies are required to enhance prognostic accuracy and explore rehabilitation's impact.
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