{"title":"BCG-PSN对带状疱疹后神经痛的作用及免疫机制：一项单盲、随机对照试验。","authors":"Yan Wu, Mi Gan, Jianbo Wu","doi":"10.29271/jcpsp.2025.05.590","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic effect of the immune modulator Bacillus Calmette-Guerin polysaccharide and nucleic acid injection (BCG-PSN) on postherpetic neuralgia (PHN), and measure immune-related markers to elucidate the immune mechanism of BCG-PSN in treating patients with PHN with neuropathic pain.</p><p><strong>Study design: </strong>Single-masked randomised controlled trial. Place and Duration of the Study: Department of Dermatology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China, from January 2022 to December 2023.</p><p><strong>Methodology: </strong>Ninety-eight patients with PHN were randomly assigned to receive oral administration of gabapentin (control group, n = 49), or a combination of gabapentin and locally injected BCG-PSN (BCG-PSN group, n = 49) for eight weeks. Two-sample and paired t-tests were used to measure the visual analogue scale (VAS) and quality of life (QOL) scores. Immune-related markers were measured in peripheral blood samples using flow cytometric staining. The χ2 test was used to compare the incidence of adverse reactions.</p><p><strong>Results: </strong>The VAS and QOL scores in the BCG-PSN group were significantly better than those of the control group (p <0.001 and p = 0.002). The CD3+, CD4+, CD19+, and CD56+ cells and the CD4+/CD8+ ratio of the BCG-PSN group were statistically lower than those of the control group (p <0.05). No significant differences were observed in the incidence of adverse reactions between the two groups (p = 0.804).</p><p><strong>Conclusion: </strong>The results indicated that BCG-PSN could effectively alleviate pain and improve immune function in patients with PHN.</p><p><strong>Key words: </strong>BCG-PSN, Postherpetic neuralgia, Immune modulation, Neuropathic pain, Gabapentin.</p>","PeriodicalId":54905,"journal":{"name":"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan","volume":"35 5","pages":"590-595"},"PeriodicalIF":0.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect and Immune Mechanism of BCG-PSN on Postherpetic Neuralgia: A Single-Masked, Randomised Controlled Trial.\",\"authors\":\"Yan Wu, Mi Gan, Jianbo Wu\",\"doi\":\"10.29271/jcpsp.2025.05.590\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the therapeutic effect of the immune modulator Bacillus Calmette-Guerin polysaccharide and nucleic acid injection (BCG-PSN) on postherpetic neuralgia (PHN), and measure immune-related markers to elucidate the immune mechanism of BCG-PSN in treating patients with PHN with neuropathic pain.</p><p><strong>Study design: </strong>Single-masked randomised controlled trial. Place and Duration of the Study: Department of Dermatology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China, from January 2022 to December 2023.</p><p><strong>Methodology: </strong>Ninety-eight patients with PHN were randomly assigned to receive oral administration of gabapentin (control group, n = 49), or a combination of gabapentin and locally injected BCG-PSN (BCG-PSN group, n = 49) for eight weeks. Two-sample and paired t-tests were used to measure the visual analogue scale (VAS) and quality of life (QOL) scores. Immune-related markers were measured in peripheral blood samples using flow cytometric staining. The χ2 test was used to compare the incidence of adverse reactions.</p><p><strong>Results: </strong>The VAS and QOL scores in the BCG-PSN group were significantly better than those of the control group (p <0.001 and p = 0.002). The CD3+, CD4+, CD19+, and CD56+ cells and the CD4+/CD8+ ratio of the BCG-PSN group were statistically lower than those of the control group (p <0.05). No significant differences were observed in the incidence of adverse reactions between the two groups (p = 0.804).</p><p><strong>Conclusion: </strong>The results indicated that BCG-PSN could effectively alleviate pain and improve immune function in patients with PHN.</p><p><strong>Key words: </strong>BCG-PSN, Postherpetic neuralgia, Immune modulation, Neuropathic pain, Gabapentin.</p>\",\"PeriodicalId\":54905,\"journal\":{\"name\":\"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan\",\"volume\":\"35 5\",\"pages\":\"590-595\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.29271/jcpsp.2025.05.590\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jcpsp-Journal of the College of Physicians and Surgeons Pakistan","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.29271/jcpsp.2025.05.590","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Effect and Immune Mechanism of BCG-PSN on Postherpetic Neuralgia: A Single-Masked, Randomised Controlled Trial.
Objective: To investigate the therapeutic effect of the immune modulator Bacillus Calmette-Guerin polysaccharide and nucleic acid injection (BCG-PSN) on postherpetic neuralgia (PHN), and measure immune-related markers to elucidate the immune mechanism of BCG-PSN in treating patients with PHN with neuropathic pain.
Study design: Single-masked randomised controlled trial. Place and Duration of the Study: Department of Dermatology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China, from January 2022 to December 2023.
Methodology: Ninety-eight patients with PHN were randomly assigned to receive oral administration of gabapentin (control group, n = 49), or a combination of gabapentin and locally injected BCG-PSN (BCG-PSN group, n = 49) for eight weeks. Two-sample and paired t-tests were used to measure the visual analogue scale (VAS) and quality of life (QOL) scores. Immune-related markers were measured in peripheral blood samples using flow cytometric staining. The χ2 test was used to compare the incidence of adverse reactions.
Results: The VAS and QOL scores in the BCG-PSN group were significantly better than those of the control group (p <0.001 and p = 0.002). The CD3+, CD4+, CD19+, and CD56+ cells and the CD4+/CD8+ ratio of the BCG-PSN group were statistically lower than those of the control group (p <0.05). No significant differences were observed in the incidence of adverse reactions between the two groups (p = 0.804).
Conclusion: The results indicated that BCG-PSN could effectively alleviate pain and improve immune function in patients with PHN.
期刊介绍：
Journal of College of Physicians and Surgeons Pakistan (JCPSP), is the prestigious, peer reviewed monthly biomedical journal of the country published regularly since 1991.
Established with the primary aim of promotion and dissemination of medical research and contributed by scholars of biomedical sciences from Pakistan and abroad, it carries original research papers, , case reports, review articles, articles on medical education, commentaries, short communication, new technology, editorials and letters to the editor. It covers the core biomedical health science subjects, basic medical sciences and emerging community problems, prepared in accordance with the “Uniform requirements for submission to bio-medical journals” laid down by International Committee of Medical Journals Editors (ICMJE). All publications of JCPSP are peer reviewed by subject specialists from Pakistan and locally and abroad.
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