Estimating the Direct Medical Costs of Smoking-Attributable Non-communicable Diseases in Northeastern Iran From 2015 to 2023.

Introduction: Smoking remains a significant public health issue, leading to severe non-communicable diseases (NCDs) and a considerable economic burden, particularly in low- and middle-income countries. In Iran, smoking-attributable diseases account for substantial healthcare costs. This study aims to estimate the direct medical costs of smoking-attributable NCDs in hospitals affiliated with Mashhad University of Medical Sciences from 2015 to 2023. Methods: A descriptive-analytical study was conducted using a cross-sectional design, analyzing hospital records from 2015 to 2023. The study population included all patients aged 35 and older with smoking-attributable NCDs hospitalized during this period. The smoking-attributable fraction (SAF) was calculated using prevalence data for current and former smokers and relative risk estimates for various NCDs. Direct medical costs were extracted from the hospital information system and analyzed using Microsoft Excel 2019 and STATA 14 software. Results: The total direct medical costs of smoking-related NCDs averaged $10.5 million annually, with male patients accounting for 93.4% of these costs. Cardiovascular diseases were the largest cost driver, comprising 74.1% of the total expenses, followed by respiratory diseases (15.2%) and cancers (10.7%). The attributable risk for smoking-related diseases was consistently higher in men, particularly for lung cancer (76.9%) and chronic obstructive pulmonary disease (68.3%). Conclusion: Smoking imposes a significant financial burden on the healthcare system, particularly for male patients. Targeted tobacco control interventions, such as increased taxation and public awareness campaigns, are urgently needed to reduce smoking prevalence and mitigate its economic impact on healthcare systems. Comprehensive policies could alleviate the strain on Iran's healthcare system and improve public health outcomes.