Imed Taleb, Sarah Witmeyer, Hélène Charitansky, Sophie Auriol, Camille Chakiba, Nathalie Quenel Tueux, Adeline Petit, Benoite Méry, Wafa Bouleftour, Nicolas Magné
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Adenoid Cystic Carcinoma of the Breast and Adjuvant Radiation Therapy: A Review of Literature.
Objectives: Adenoid cystic carcinoma (ACC) of the breast is a rare special histologic type of breast cancer. This tumor is classified as low-grade and has a favorable prognosis, with rare occurrence of metastasis and distinctive characteristics. Due to the uncommon nature of this tumor, there are no specific recommendations regarding the therapeutic management of this malignancy. The aim of this review was to provide an overview of breast ACC clinical characteristics with a special focus on radiotherapy management.
Methods: A literature review was conducted up to January 2024 through a PubMed search using different combinations of pertinent keywords (eg, Adenoid cystic carcinoma alone, Adenoid cystic carcinoma AND breast Cancer AND radiotherapy; Adenoid cystic carcinoma AND breast cancer AND radiation therapy).
Results: This review highlighted the lack of prospective and randomized data guiding treatment algorithms for ACC. Four retrospective studies explored the impact of postoperative radiation and concluded that postoperative radiation contributes to improved survival.
Conclusions: Thus, a consideration for radiotherapy indications in ACC of the breast could be further elucidated through prospective randomized studies.
期刊介绍:
American Journal of Clinical Oncology is a multidisciplinary journal for cancer surgeons, radiation oncologists, medical oncologists, GYN oncologists, and pediatric oncologists.
The emphasis of AJCO is on combined modality multidisciplinary loco-regional management of cancer. The journal also gives emphasis to translational research, outcome studies, and cost utility analyses, and includes opinion pieces and review articles.
The editorial board includes a large number of distinguished surgeons, radiation oncologists, medical oncologists, GYN oncologists, pediatric oncologists, and others who are internationally recognized for expertise in their fields.