荧光成像评估头颈部肿瘤手术边缘检测的被动和主动靶向。

IF 4.1 3区 医学 Q1 GENETICS & HEREDITY
L Dirheimer, S Cortese, G Dolivet, J L Merlin, F Marchal, R Mastronicola, L Bezdetnaya
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引用次数: 0

摘要

手术仍然是头颈部鳞状细胞癌(HNSCC)治疗的金标准。然而,这些癌症的解剖复杂性,加上难以区分健康组织和癌组织以及微病变的检测,使肿瘤切除复杂化,导致手术切缘阳性,这与患者预后不良有关。荧光引导手术(FGS)已成为一种很有前途的技术,在管理HNSCC,改善肿瘤切除和边缘评估。FGS策略大致可分为三种方法;即,自然组织自身荧光,荧光造影剂的被动传递和主动靶向。本文综述了FGS在头颈癌诊断中的进展,特别是在改善手术切缘评估方面的进展。最近,对比剂靶向过表达的表皮生长因子受体(EGFR),在临床前和临床环境中都显示出有希望的结果。αVβ6整合素、uPAR、PARP1等新靶点的发现以及造影剂的开发是FGS进一步发展头颈部肿瘤的关键步骤,使其成为精准肿瘤学的重要工具。其中,临床前研究表明,αVβ6整合素因其在肿瘤和肿瘤边缘的高特异性表达而成为一个有希望的靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fluorescence Imaging-Assessed Surgical Margin Detection in Head and Neck Oncology by Passive and Active Targeting.

Surgery remains the gold standard in the management of head and neck squamous cell carcinoma (HNSCC). However, the anatomical complexity of these cancers, combined with the difficulty in discriminating between healthy and cancerous tissue and the detection of microlesions, complicates tumor resection, resulting in positive surgical margins, which are associated with a poor patient prognosis. Fluorescence-guided surgery (FGS) has emerged as a promising technique in the management of HNSCC, improving tumor resection and margin assessment. FGS strategies can be roughly divided into three approaches; namely, natural tissue autofluorescence, passive delivery of fluorescent contrast agents, and active targeting. This review provides a comprehensive overview of the advances made in FGS of head and neck cancers, particularly aiming to improve surgical margin assessment. Recently, the field has shown promising results by addressing contrast agents targeted to the overexpressed epidermal growth factor receptor (EGFR), both in preclinical and clinical settings. The identification of new targets such as αVβ6 integrin, uPAR, PARP1, and so on, as well as the development of contrast agents, are key steps in the further development of FGS of head and neck cancers, making it an essential tool in precision oncology. Among these, as was demonstrated in preclinical studies, the αVβ6 integrin is emerging as a promising target due to its high and specific expression in tumor and tumor margins.

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来源期刊
CiteScore
7.80
自引率
2.50%
发文量
53
审稿时长
>12 weeks
期刊介绍: Molecular Diagnosis & Therapy welcomes current opinion articles on emerging or contentious issues, comprehensive narrative reviews, systematic reviews (as outlined by the PRISMA statement), original research articles (including short communications) and letters to the editor. All manuscripts are subject to peer review by international experts.
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