关于“右美托咪定鼻内与艾氯胺酮鼻内用于幼儿程序性镇静镇痛的随机双盲试验”的评论。

IF 3.1 2区医学 Q1 EMERGENCY MEDICINE

Scandinavian Journal of Trauma Resuscitation & Emergency Medicine Pub Date : 2025-05-13 DOI:10.1186/s13049-025-01403-5

Jiajing Wang

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引用次数: 0

摘要

这篇评论批评了一项比较鼻内右美托咪定（DEX）和艾氯胺酮（sKET）用于儿科手术镇静的试验。尽管效应量很大，但小样本（n = 29）可能导致假阴性结果（p = 0.09），因此需要更大规模的试验。安全性问题（如误吸风险）、未解决的长期心理结果和有限的药代动力学数据（DEX起效延迟、持续时间延长）挑战了其临床适用性。未来的研究应结合客观测量和长期随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comment on "A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children".

This comment critiques a trial comparing intranasal dexmedetomidine (DEX) and esketamine (sKET) for pediatric procedural sedation. Despite a large effect size, the small sample (n = 29) likely caused false-negative results (p = 0.09), necessitating larger trials. Safety concerns (e.g., aspiration risk), unaddressed long-term psychological outcomes, and limited pharmacokinetic data (delayed DEX onset, prolonged duration) challenge clinical applicability. Future studies should integrate objective measures and long-term follow-up.

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来源期刊

Scandinavian Journal of Trauma Resuscitation & Emergency Medicine EMERGENCY MEDICINE-

CiteScore

6.10

自引率

6.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The primary topics of interest in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine (SJTREM) are the pre-hospital and early in-hospital diagnostic and therapeutic aspects of emergency medicine, trauma, and resuscitation. Contributions focusing on dispatch, major incidents, etiology, pathophysiology, rehabilitation, epidemiology, prevention, education, training, implementation, work environment, as well as ethical and socio-economic aspects may also be assessed for publication.