Mathilde Toschini, Isabella Colizzi, Antony John Lomax, Serena Psoroulas
{"title":"医学物理数据集文章：FLASH小鼠体内研究数据库。","authors":"Mathilde Toschini, Isabella Colizzi, Antony John Lomax, Serena Psoroulas","doi":"10.1002/mp.17744","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>The FLASH effect refers to a lower normal tissue damage for an equivalent tumor response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types of particles and irradiation parameters, the underlying mechanism is not yet clearly understood. Uncertainties surround the conducted experiments, the explored parameter space, and the variability of reported results. To gain a better overview, we have created a dataset that includes in vivo FLASH experiments. This dataset documents all machine and biological dosimetric parameters, and for determined endpoints, it includes the outcome of the experiment. Our goal with this database is to increase awareness of the results and their variability and provide a useful research and analysis tool for the community.</p>\n </section>\n \n <section>\n \n <h3> Acquisition and Validation Methods</h3>\n \n <p>The database contains peer-reviewed papers published until March 2024 on the FLASH in vivo (murine) experiments. From each paper, previously defined parameters have been manually extracted and/or recalculated to ensure compatibility within the database entries.</p>\n </section>\n \n <section>\n \n <h3> Data Format and Usage Notes</h3>\n \n <p>We provide two types of datasets: a user-friendly web-based Notion database and spreadsheets on a Zenodo repository. The database contains all the reviewed papers with extracted information in text or numeric form. Users can duplicate the database or view, search, filter, and reorganize online entries. The spreadsheets contain the data for the most analyzed endpoints (skin toxicity, survival rate, and crypt cells), allowing a comparative analysis.</p>\n </section>\n \n <section>\n \n <h3> Potential Applications</h3>\n \n <p>The study has two main applications. The web-based database will allow for a user-friendly search of information and metadata of all published FLASH murine data. This will facilitate future research efforts to better understand the FLASH effect. The spreadsheets are a simple and useful tool for the community to conduct statistical analysis and determine the parameters associated with the FLASH effect.</p>\n </section>\n </div>","PeriodicalId":18384,"journal":{"name":"Medical physics","volume":"52 6","pages":"5115-5123"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mp.17744","citationCount":"0","resultStr":"{\"title\":\"Medical physics dataset article: A database of FLASH murine in vivo studies\",\"authors\":\"Mathilde Toschini, Isabella Colizzi, Antony John Lomax, Serena Psoroulas\",\"doi\":\"10.1002/mp.17744\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Purpose</h3>\\n \\n <p>The FLASH effect refers to a lower normal tissue damage for an equivalent tumor response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types of particles and irradiation parameters, the underlying mechanism is not yet clearly understood. Uncertainties surround the conducted experiments, the explored parameter space, and the variability of reported results. To gain a better overview, we have created a dataset that includes in vivo FLASH experiments. This dataset documents all machine and biological dosimetric parameters, and for determined endpoints, it includes the outcome of the experiment. Our goal with this database is to increase awareness of the results and their variability and provide a useful research and analysis tool for the community.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Acquisition and Validation Methods</h3>\\n \\n <p>The database contains peer-reviewed papers published until March 2024 on the FLASH in vivo (murine) experiments. From each paper, previously defined parameters have been manually extracted and/or recalculated to ensure compatibility within the database entries.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Data Format and Usage Notes</h3>\\n \\n <p>We provide two types of datasets: a user-friendly web-based Notion database and spreadsheets on a Zenodo repository. The database contains all the reviewed papers with extracted information in text or numeric form. Users can duplicate the database or view, search, filter, and reorganize online entries. The spreadsheets contain the data for the most analyzed endpoints (skin toxicity, survival rate, and crypt cells), allowing a comparative analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Potential Applications</h3>\\n \\n <p>The study has two main applications. The web-based database will allow for a user-friendly search of information and metadata of all published FLASH murine data. 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Medical physics dataset article: A database of FLASH murine in vivo studies
Purpose
The FLASH effect refers to a lower normal tissue damage for an equivalent tumor response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types of particles and irradiation parameters, the underlying mechanism is not yet clearly understood. Uncertainties surround the conducted experiments, the explored parameter space, and the variability of reported results. To gain a better overview, we have created a dataset that includes in vivo FLASH experiments. This dataset documents all machine and biological dosimetric parameters, and for determined endpoints, it includes the outcome of the experiment. Our goal with this database is to increase awareness of the results and their variability and provide a useful research and analysis tool for the community.
Acquisition and Validation Methods
The database contains peer-reviewed papers published until March 2024 on the FLASH in vivo (murine) experiments. From each paper, previously defined parameters have been manually extracted and/or recalculated to ensure compatibility within the database entries.
Data Format and Usage Notes
We provide two types of datasets: a user-friendly web-based Notion database and spreadsheets on a Zenodo repository. The database contains all the reviewed papers with extracted information in text or numeric form. Users can duplicate the database or view, search, filter, and reorganize online entries. The spreadsheets contain the data for the most analyzed endpoints (skin toxicity, survival rate, and crypt cells), allowing a comparative analysis.
Potential Applications
The study has two main applications. The web-based database will allow for a user-friendly search of information and metadata of all published FLASH murine data. This will facilitate future research efforts to better understand the FLASH effect. The spreadsheets are a simple and useful tool for the community to conduct statistical analysis and determine the parameters associated with the FLASH effect.
期刊介绍：
Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments
Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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