母体血红蛋白病和缺铁性贫血对胎儿生长受限的影响:系统回顾和荟萃分析。

IF 2.8 2区 医学 Q3 NUTRITION & DIETETICS
Rajeev Jayalakshmi, Shilpa Gaidhane, Suhas Ballal, Sanjay Kumar, Mahakshit Bhat, Shilpa Sharma, M. Ravi Kumar, Sarvesh Rustagi, Mahalaqua Nazli Khatib, Nishant Rai, Sanjit Sah, Sorabh Lakhanpal, Hashem Abu Serhan, Ganesh Bushi, Muhammed Shabil
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引用次数: 0

摘要

孕产妇贫血是一个重大的全球健康问题,对孕产妇和胎儿的结局,特别是宫内生长受限(IUGR)产生不利影响。本系统综述和荟萃分析旨在巩固孕产妇贫血对IUGR风险影响的现有证据。我们在PubMed, Embase, Cochrane和Web of Science上进行了全面的搜索,直到2024年2月28日。符合条件的研究包括报告母体贫血及其与IUGR或小于胎龄(SGA)结局相关的观察性设计。采用随机效应模型计算合并优势比(or),采用I²统计量评估异质性。采用R软件(版本4.3)进行统计分析。共纳入38项研究,涉及3,871,849名贫血孕妇和27,978,450名非贫血孕妇。合并分析表明,妊娠期贫血与IUGR风险显著增加相关(OR = 1.30, 95% CI: 1.05-1.62, I²= 97%)。根据贫血严重程度进行的亚组分析显示,轻度贫血(OR = 0.84, 95% CI: 0.58-1.23)和中度贫血(OR = 0.98, 95% CI: 0.48-1.98)与IUGR的风险无显著关联,而重度贫血则表明IUGR的风险较高(OR = 1.42, 95% CI: 0.69-2.93)。孕产妇贫血与IUGR风险增加有关,突出了在产前护理环境中采取有效管理和早期干预策略的迫切需要。未来的研究应侧重于阐明不同贫血程度对出生结果的影响,包括IUGR和生命后期的长期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta-Analysis

The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta-Analysis

Maternal anaemia is a significant global health issue that adversely affects both maternal and foetal outcomes, particularly, intrauterine growth restriction (IUGR). This systematic review and meta-analysis aimed to consolidate existing evidence on the impact of maternal anaemia on the risk of IUGR. We conducted a comprehensive search across PubMed, Embase, Cochrane and Web of Science until 28 February 2024. Eligible studies included observational designs that reported maternal anaemia and its association with IUGR or small for gestational age (SGA) outcomes. The pooled odds ratios (ORs) were calculated using a random-effects model and heterogeneity was assessed with the I² statistic. The R software (version 4.3) was used for statistical analyses. A total of 38 studies involving 3,871,849 anaemic and 27,978,450 non-anaemic pregnant women were included. The pooled analysis demonstrated that anaemia in pregnancy is associated with a significantly increased risk of IUGR (OR = 1.30, 95% CI: 1.05–1.62, I² = 97%). Subgroup analyses by anaemia severity showed non-significant associations for mild (OR = 0.84, 95% CI: 0.58–1.23) and moderate anaemia (OR = 0.98, 95% CI: 0.48–1.98), while severe anaemia indicated a higher, though non-significant, risk of IUGR (OR = 1.42, 95% CI: 0.69–2.93). Maternal anaemia is associated with a heightened risk of IUGR, highlighting the critical need for effective management and early intervention strategies within prenatal care settings. Future research should focus on elucidating the effects of different severities of anaemia on birth outcomes, including IUGR and long-term effects later in life.

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来源期刊
Maternal and Child Nutrition
Maternal and Child Nutrition 医学-小儿科
CiteScore
7.70
自引率
8.80%
发文量
144
审稿时长
6-12 weeks
期刊介绍: Maternal & Child Nutrition addresses fundamental aspects of nutrition and its outcomes in women and their children, both in early and later life, and keeps its audience fully informed about new initiatives, the latest research findings and innovative ways of responding to changes in public attitudes and policy. Drawing from global sources, the Journal provides an invaluable source of up to date information for health professionals, academics and service users with interests in maternal and child nutrition. Its scope includes pre-conception, antenatal and postnatal maternal nutrition, women''s nutrition throughout their reproductive years, and fetal, neonatal, infant, child and adolescent nutrition and their effects throughout life.
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