J Goralska, U Razny, A Gruca, B Solnica, M Malczewska-Malec
{"title":"肥胖患者体重减轻后胰岛素敏感性的改善与循环肌生长抑制素有关。","authors":"J Goralska, U Razny, A Gruca, B Solnica, M Malczewska-Malec","doi":"10.26402/jpp.2025.2.02","DOIUrl":null,"url":null,"abstract":"<p><p>Increased levels of myostatin, a negative regulator of skeletal muscle development, have been shown in obesity and associated with dysregulated energy metabolism. There is growing interest on dietary factors behind muscle training, that regulate circulating myostatin levels. The aim of the study was to assess the effect of weight loss after a 3-month hypocaloric diet on plasma myostatin concentration in obese patients and to examine whether the myostatin level affects the effectiveness of the hypocaloric diet. The study involved 73 obese patients using hypocaloric (HCD) or control normocaloric (NCD) diet. Body weight and composition as well as biomarkers of glucose and lipid metabolism and plasma myostatin were measured before and after 3-month diet. The use of a 3-month hypocaloric diet, without changing of physical activity, markedly reduced BMI (-7.7% in HCD vs. -0.9% in NCD), body fat, influenced postprandial insulin sensitivity and improved plasma lipid profile. The dietary intervention did not influence muscle mass as well as plasma myostatin levels in the whole cohort, although the highest myostatin levels were normalized after 3 month to average values. Only the group with initially higher levels of myostatin (>21.18 ng/mL) achieved an improvement in carbohydrate metabolism. Results showed that obese patients who experienced a decrease in plasma myostatin concentration after a 3-month HCD had greater improvement in glucose metabolism, fasting and postprandial, than obese patients without reduction in circulating myostatin (correlations of Δ myostatin with Δ fasting glucose Rho=0.42, p<0.001; Δ myostatin with Δ glucose AUC OGTT Rho=0.33, p=0.005). In conclusion, increased circulating myostatin may be involved in the development of insulin resistance but does not significantly affect lipid complications in obese patients. A hypocaloric diet may only affect the highest myostatin values in obese individuals.</p>","PeriodicalId":50089,"journal":{"name":"Journal of Physiology and Pharmacology","volume":"76 2","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Improvement in insulin sensitivity following weight loss in obese patients is associated with circulating myostatin.\",\"authors\":\"J Goralska, U Razny, A Gruca, B Solnica, M Malczewska-Malec\",\"doi\":\"10.26402/jpp.2025.2.02\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Increased levels of myostatin, a negative regulator of skeletal muscle development, have been shown in obesity and associated with dysregulated energy metabolism. There is growing interest on dietary factors behind muscle training, that regulate circulating myostatin levels. The aim of the study was to assess the effect of weight loss after a 3-month hypocaloric diet on plasma myostatin concentration in obese patients and to examine whether the myostatin level affects the effectiveness of the hypocaloric diet. The study involved 73 obese patients using hypocaloric (HCD) or control normocaloric (NCD) diet. Body weight and composition as well as biomarkers of glucose and lipid metabolism and plasma myostatin were measured before and after 3-month diet. The use of a 3-month hypocaloric diet, without changing of physical activity, markedly reduced BMI (-7.7% in HCD vs. -0.9% in NCD), body fat, influenced postprandial insulin sensitivity and improved plasma lipid profile. The dietary intervention did not influence muscle mass as well as plasma myostatin levels in the whole cohort, although the highest myostatin levels were normalized after 3 month to average values. Only the group with initially higher levels of myostatin (>21.18 ng/mL) achieved an improvement in carbohydrate metabolism. Results showed that obese patients who experienced a decrease in plasma myostatin concentration after a 3-month HCD had greater improvement in glucose metabolism, fasting and postprandial, than obese patients without reduction in circulating myostatin (correlations of Δ myostatin with Δ fasting glucose Rho=0.42, p<0.001; Δ myostatin with Δ glucose AUC OGTT Rho=0.33, p=0.005). In conclusion, increased circulating myostatin may be involved in the development of insulin resistance but does not significantly affect lipid complications in obese patients. 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引用次数: 0
摘要
肌生长抑制素(骨骼肌发育的负调节因子)水平升高已被证明与肥胖和能量代谢失调有关。人们对肌肉训练背后的饮食因素越来越感兴趣,因为它可以调节循环肌肉生长抑制素的水平。该研究的目的是评估3个月低热量饮食后体重减轻对肥胖患者血浆肌生长抑制素浓度的影响,并检查肌生长抑制素水平是否影响低热量饮食的有效性。该研究涉及73名使用低热量(HCD)或控制正常热量(NCD)饮食的肥胖患者。测定饮食前后3个月的体重、组成、糖脂代谢生物标志物和血浆肌生长抑制素。使用3个月的低热量饮食,不改变身体活动,显著降低BMI (HCD组-7.7%,NCD组-0.9%),体脂,影响餐后胰岛素敏感性和改善血脂。饮食干预对整个队列的肌肉质量和血浆肌生长抑制素水平没有影响,尽管最高肌生长抑制素水平在3个月后恢复到平均值。只有最初肌肉生长抑制素水平较高的组(>21.18 ng/mL)实现了碳水化合物代谢的改善。结果显示,3个月HCD后血浆肌生长抑制素浓度降低的肥胖患者比循环肌生长抑制素未降低的肥胖患者在糖代谢、空腹和餐后有更大的改善(Δ肌生长抑制素与Δ空腹血糖的相关性Rho=0.42, p
Improvement in insulin sensitivity following weight loss in obese patients is associated with circulating myostatin.
Increased levels of myostatin, a negative regulator of skeletal muscle development, have been shown in obesity and associated with dysregulated energy metabolism. There is growing interest on dietary factors behind muscle training, that regulate circulating myostatin levels. The aim of the study was to assess the effect of weight loss after a 3-month hypocaloric diet on plasma myostatin concentration in obese patients and to examine whether the myostatin level affects the effectiveness of the hypocaloric diet. The study involved 73 obese patients using hypocaloric (HCD) or control normocaloric (NCD) diet. Body weight and composition as well as biomarkers of glucose and lipid metabolism and plasma myostatin were measured before and after 3-month diet. The use of a 3-month hypocaloric diet, without changing of physical activity, markedly reduced BMI (-7.7% in HCD vs. -0.9% in NCD), body fat, influenced postprandial insulin sensitivity and improved plasma lipid profile. The dietary intervention did not influence muscle mass as well as plasma myostatin levels in the whole cohort, although the highest myostatin levels were normalized after 3 month to average values. Only the group with initially higher levels of myostatin (>21.18 ng/mL) achieved an improvement in carbohydrate metabolism. Results showed that obese patients who experienced a decrease in plasma myostatin concentration after a 3-month HCD had greater improvement in glucose metabolism, fasting and postprandial, than obese patients without reduction in circulating myostatin (correlations of Δ myostatin with Δ fasting glucose Rho=0.42, p<0.001; Δ myostatin with Δ glucose AUC OGTT Rho=0.33, p=0.005). In conclusion, increased circulating myostatin may be involved in the development of insulin resistance but does not significantly affect lipid complications in obese patients. A hypocaloric diet may only affect the highest myostatin values in obese individuals.
期刊介绍:
Journal of Physiology and Pharmacology publishes papers which fall within the range of basic and applied physiology, pathophysiology and pharmacology. The papers should illustrate new physiological or pharmacological mechanisms at the level of the cell membrane, single cells, tissues or organs. Clinical studies, that are of fundamental importance and have a direct bearing on the pathophysiology will also be considered. Letters related to articles published in The Journal with topics of general professional interest are welcome.