揭示ADAR和APOBEC蛋白基因家族的RNA编辑。

IF 3.3 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Alexander Modestov, Anton Buzdin, Maria Suntsova
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引用次数: 0

摘要

RNA编辑是一种至关重要的转录后修饰,它改变转录组和蛋白质组,影响许多细胞过程,包括剪接、microRNA特异性、RNA分子稳定性和蛋白质结构。来自腺苷脱氨酶作用于RNA (ADAR)和载脂蛋白B mRNA编辑催化多肽样(APOBEC)蛋白家族的酶介导RNA编辑,并可以改变各种非编码和编码RNA,包括mRNA分子的所有区域,导致肿瘤的发生和进展。这篇综述为RNA编辑参数的潜在用途提供了新的见解,如编辑水平、ADAR和APOBEC基因的表达,以及专门编辑的基因,作为癌症进展的生物标志物,将其与以往专注于RNA编辑机制的孤立方面的研究区分开来。方法学部分提供了线索,以加速RNA或DNA测序数据的高通量分析,以识别RNA编辑事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families.

RNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure. Enzymes from the adenosine deaminase acting on RNA (ADAR) and apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) protein families mediate RNA editing and can alter a variety of non-coding and coding RNAs, including all regions of mRNA molecules, leading to tumor development and progression. This review provides novel insights into the potential use of RNA editing parameters, such as editing levels, expression of ADAR and APOBEC genes, and specifically edited genes, as biomarkers for cancer progression, distinguishing it from previous studies that focused on isolated aspects of RNA editing mechanisms. The methodological section offers clues to accelerate high-throughput analysis of RNA or DNA sequencing data for the identification of RNA editing events.

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