{"title":"肾细胞癌患者术前血清胱抑素C水平与术后肿瘤预后的关系：1641例患者的系统回顾和荟萃分析","authors":"Shuai Lu, Yulin Wang, Zhongbao Zhou, Yong Zhang, Liqing Yang, Xudong Yang","doi":"10.1007/s13304-025-02208-y","DOIUrl":null,"url":null,"abstract":"<p><p>An increasing number of studies have indicated that cystatin C (CysC) may serve as an effective indicator for predicting the prognosis of renal cell carcinoma (RCC). However, there was currently a lack of meta-analysis examining the influence of serum CysC on the prognosis of RCC. From April 2016 to June 2024, we ultimately selected five retrospective studies including 1641 participants to evaluate the effect of serum CysC on patients with RCC. All data were analyzed using Review Manager version 5.3. The research findings primarily focused on overall survival (OS) and disease-free survival (DFS). Both univariate and multivariate analyses were conducted to evaluate the results. Five studies involving a total of 1641 patients were selected based on predefined eligibility criteria. Univariate analysis revealed that serum CysC levels were significantly correlated with OS (P < 0.00001) and DFS (P = 0.02) in postoperative patients with RCC. Elevated serum CysC levels were considered a reliable predictor of poor prognosis in patients with RCC. Multivariate analysis indicated that high serum CysC levels were an independent risk factor for OS (P < 0.00001) and DFS (P = 0.006) in postoperative patients with RCC, remaining unaffected by other factors. Our research results indicated that elevated serum CysC levels were associated with reduced OS and DFS in patients with RCC. However, caution must be exercised before making recommendations as this interpretation was based on very few clinical studies and small samples.</p>","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The relationship between preoperative serum cystatin C levels and postoperative oncologic outcomes in patients with renal cell carcinoma: a systematic review and meta-analysis of 1641 patients.\",\"authors\":\"Shuai Lu, Yulin Wang, Zhongbao Zhou, Yong Zhang, Liqing Yang, Xudong Yang\",\"doi\":\"10.1007/s13304-025-02208-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>An increasing number of studies have indicated that cystatin C (CysC) may serve as an effective indicator for predicting the prognosis of renal cell carcinoma (RCC). However, there was currently a lack of meta-analysis examining the influence of serum CysC on the prognosis of RCC. From April 2016 to June 2024, we ultimately selected five retrospective studies including 1641 participants to evaluate the effect of serum CysC on patients with RCC. All data were analyzed using Review Manager version 5.3. The research findings primarily focused on overall survival (OS) and disease-free survival (DFS). Both univariate and multivariate analyses were conducted to evaluate the results. Five studies involving a total of 1641 patients were selected based on predefined eligibility criteria. Univariate analysis revealed that serum CysC levels were significantly correlated with OS (P < 0.00001) and DFS (P = 0.02) in postoperative patients with RCC. Elevated serum CysC levels were considered a reliable predictor of poor prognosis in patients with RCC. Multivariate analysis indicated that high serum CysC levels were an independent risk factor for OS (P < 0.00001) and DFS (P = 0.006) in postoperative patients with RCC, remaining unaffected by other factors. Our research results indicated that elevated serum CysC levels were associated with reduced OS and DFS in patients with RCC. However, caution must be exercised before making recommendations as this interpretation was based on very few clinical studies and small samples.</p>\",\"PeriodicalId\":23391,\"journal\":{\"name\":\"Updates in Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-05-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Updates in Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13304-025-02208-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Updates in Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13304-025-02208-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
The relationship between preoperative serum cystatin C levels and postoperative oncologic outcomes in patients with renal cell carcinoma: a systematic review and meta-analysis of 1641 patients.
An increasing number of studies have indicated that cystatin C (CysC) may serve as an effective indicator for predicting the prognosis of renal cell carcinoma (RCC). However, there was currently a lack of meta-analysis examining the influence of serum CysC on the prognosis of RCC. From April 2016 to June 2024, we ultimately selected five retrospective studies including 1641 participants to evaluate the effect of serum CysC on patients with RCC. All data were analyzed using Review Manager version 5.3. The research findings primarily focused on overall survival (OS) and disease-free survival (DFS). Both univariate and multivariate analyses were conducted to evaluate the results. Five studies involving a total of 1641 patients were selected based on predefined eligibility criteria. Univariate analysis revealed that serum CysC levels were significantly correlated with OS (P < 0.00001) and DFS (P = 0.02) in postoperative patients with RCC. Elevated serum CysC levels were considered a reliable predictor of poor prognosis in patients with RCC. Multivariate analysis indicated that high serum CysC levels were an independent risk factor for OS (P < 0.00001) and DFS (P = 0.006) in postoperative patients with RCC, remaining unaffected by other factors. Our research results indicated that elevated serum CysC levels were associated with reduced OS and DFS in patients with RCC. However, caution must be exercised before making recommendations as this interpretation was based on very few clinical studies and small samples.
期刊介绍：
Updates in Surgery (UPIS) has been founded in 2010 as the official journal of the Italian Society of Surgery. It’s an international, English-language, peer-reviewed journal dedicated to the surgical sciences. Its main goal is to offer a valuable update on the most recent developments of those surgical techniques that are rapidly evolving, forcing the community of surgeons to a rigorous debate and a continuous refinement of standards of care. In this respect position papers on the mostly debated surgical approaches and accreditation criteria have been published and are welcome for the future.
Beside its focus on general surgery, the journal draws particular attention to cutting edge topics and emerging surgical fields that are publishing in monothematic issues guest edited by well-known experts.
Updates in Surgery has been considering various types of papers: editorials, comprehensive reviews, original studies and technical notes related to specific surgical procedures and techniques on liver, colorectal, gastric, pancreatic, robotic and bariatric surgery.
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