预测克罗恩病患者内镜下球囊扩张后的内镜再狭窄:一种机器学习方法。

IF 2.4 2区 医学 Q2 SURGERY
Tao Su, Yi Lu, Nan Lan, Hongzhen Wu, Luying Wu, Min Zhang, Xiaoling Wang, Jiachen Sun, Jiayin Yao, Min Zhi
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引用次数: 0

摘要

背景:内镜下球囊扩张术(EBD)被认为是治疗克罗恩病(CD)患者肠道狭窄的一种微创且有效的方法。它提供了手术的另一种选择,并已被证明可以通过减少对更积极干预的需要来改善这些患者的生活质量。本研究旨在评估EBD术后内镜下再狭窄的相关因素,并建立预后模型。方法:回顾性收集中山大学附属第六医院2013年至2024年接受EBD治疗的患者资料并进行分析。使用7种机器学习(ML)算法构建预后模型。随后,我们对模型的性能进行了对比测试,以确保模型的准确性和可靠性。结果:共纳入135例患者。53%发生内镜下再狭窄,平均再狭窄时间为183天。COX和logistic回归分析显示,曾使用糖皮质激素、狭窄位置、技术成功和白蛋白水平4项特征与再狭窄风险相关。对比不同的ML模型,CoxPH和LASSO模型在各种评价指标上表现更好,包括训练和测试集的c指数均大于0.7。基于SHapley加性解释(SHAP),狭窄位置、球囊直径和白蛋白水平被确定为与预后相关的前3个重要特征。结论:基于ml的预后模型预测效果较好,能准确评估EBD治疗后内镜下再狭窄的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prediction of endoscopic restenosis after endoscopic balloon dilation in patients with Crohn's disease: a machine learning approach.

Background: Endoscopic balloon dilation (EBD) is recognized as a minimally invasive and effective procedure for managing intestinal stenosis in patients with Crohn's disease (CD). It offers an alternative to surgery and has been shown to improve the quality of life for these patients by reducing the need for more aggressive interventions. This study aimed to evaluate factors associated with endoscopic restenosis after EBD and construct a prognostic model.

Methods: We retrospectively collected and analyzed data on patients receiving EBD treatment at the Sixth Affiliated Hospital of Sun Yat-sen University from 2013 to 2024. Seven machine learning (ML) algorithms were used to construct prognostic models. Subsequently, we conducted comparative tests on the performance of the models to ensure accuracy and reliability.

Results: A total of 135 patients were included in the statistical analysis. 53% occurred endoscopic restenosis, with an average restenosis time of 183 days. COX and logistic regression analysis showed that 4 features including ever-use glucocorticoids, stenosis position, technical success, and albumin level were associated with restenosis risk. When comparing different ML models, CoxPH and LASSO models performed better on various evaluation metrics, including C-index which was greater than 0.7 in the train and test set. Based on SHapley Additive exPlanations (SHAP), stenosis position, balloon diameter, and albumin level were identified as the top 3 important features associated with prognosis.

Conclusion: The ML-based prognostic model has good predictive performance and can accurately assess the risk of endoscopic restenosis after EBD treatment.

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来源期刊
CiteScore
6.10
自引率
12.90%
发文量
890
审稿时长
6 months
期刊介绍: Uniquely positioned at the interface between various medical and surgical disciplines, Surgical Endoscopy serves as a focal point for the international surgical community to exchange information on practice, theory, and research. Topics covered in the journal include: -Surgical aspects of: Interventional endoscopy, Ultrasound, Other techniques in the fields of gastroenterology, obstetrics, gynecology, and urology, -Gastroenterologic surgery -Thoracic surgery -Traumatic surgery -Orthopedic surgery -Pediatric surgery
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